Could a simple pill make root canals less painful?
NCT ID NCT07743372
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial tests whether taking a single dose of diclofenac potassium before dental treatment can improve the numbing effect of local anesthesia and reduce pain after the procedure. Adults with severe tooth pain from irreversible pulpitis in lower molars will receive either 50mg, 100mg, or a placebo before treatment. The study measures how well the anesthesia works and how much pain is felt six hours later.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- diclofenac potassium
- What this could lead to
- If effective, a single pre-treatment dose could make dental procedures more comfortable and reduce post-procedure pain for people with severe tooth inflammation.
- What could go wrong
- This is a small early-stage trial, and results may not apply to all patients. Diclofenac can cause side effects like stomach irritation or allergic reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Other studies related to the condition(s) this trial covers.
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