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Laser light may help save infected young teeth and speed root growth

NCT ID NCT07704463

Disease control Sponsor: Alexandria University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This trial tests whether using a low-power laser during a pulpotomy (removing infected pulp from a tooth) can improve healing and root formation in children aged 6 to 14 with painful, irreversible pulpitis in immature permanent molars. Participants receive either laser treatment plus a standard capping material (MTA), laser at a different wavelength plus MTA, or MTA alone. The study tracks pain, dentin bridge formation, and overall success over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
laser therapy (660 nm and 970 nm diode lasers) combined with mineral trioxide aggregate (MTA) capping material
What this could lead to
If successful, this approach could offer a faster, less painful treatment for saving infected young permanent teeth and promoting natural root development.
What could go wrong
This is a small, early-stage trial with only 57 participants, so results may not apply to all cases. Laser effects on pain and healing are still uncertain, and long-term success beyond 12 months is unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

57 people

The number who actually took part.

Started

Jan 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 14 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children with an age ranging between 6 to 14 years old with no gender predilection. * Children free of any systemic disease or special health care needs. * Patients complaining from intermittent or spontaneous, sharp, localized, diffuse, or referred pain. * Selected teeth should give long lasting positive responses to cold testing. * Soft tissues around the tooth are normal. * Periapical radiographs show deep carious lesions. * Patients with immature permanent molars (stages 8 and 9) according to Nolla's classification for tooth developmental stage. * Periapical index score 1 or 2. * Following pulpal amputation, hemostasis could be easily achievable within 5 to 10 minutes with a sterile moist cotton pellet. Exclusion Criteria: * Child with bad experience of dental treatment (uncooperative patient). * Non-restorable teeth. * Negative response to cold testing. * Bleeding could not be controlled. * Absence of bleeding from any of the canals. * Pus discharge through an associated sinus tract. * Pulpal calcifications * Radiographic signs of internal or external resorption.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Symptomatic irreversible pulpitis (SIP)

Contacts and locations

Locations

  • Faculty of Dentistry

    Alexandria, Egypt

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