Can a digestive enzyme combo beat standard painkillers for root canal pain?
NCT ID NCT07759349
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests three pain-relief approaches after a single-visit root canal in people with symptomatic irreversible pulpitis, a painful tooth condition. Participants receive either acetaminophen, an NSAID, or a combination of trypsin-chymotrypsin with acetaminophen for three days. Pain levels are measured before treatment and at several points over 72 hours using a standard pain scale. The goal is to see which option provides the best relief after the procedure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Acetaminophen, NSAIDs (ibuprofen), and a combination of trypsin-chymotrypsin with acetaminophen
- What this could lead to
- If successful, this could identify the most effective painkiller for post-root-canal discomfort, helping dentists choose better pain management strategies.
- What could go wrong
- This is a small early-phase trial, so results may not apply to all patients. Pain relief can vary widely, and the study doesn't guarantee long-term benefits or account for all individual differences.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dow University of Health Sciences
RECRUITINGKarachi, Sindh, 75600, Pakistan
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