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New study finds better numbing for painful tooth procedures

NCT ID NCT07506265

Symptom relief Sponsor: Fayoum University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether injecting dexamethasone, diclofenac sodium, or chymotrypsin into the gum before numbing medicine can make dental treatment less painful. 105 men with severe toothache took part. The goal was to see if these drugs help the numbing work better so patients need fewer extra shots.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

105 people

The number who actually took part.

Started

May 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy male patients (ASA I or II) * Aged 18 to 50 years * Presenting with symptomatic irreversible pulpitis in a restorable mandibular molar * Preoperative moderate to severe pain (VAS ≥45 mm) * Normal periapical tissue (no radiolucency, pocket depth ≤5 mm, mobility ≤ Grade I) Exclusion Criteria: * Medically compromised patients (ASA III or higher) * History of allergy or intolerance to chymotrypsin, dexamethasone, diclofenac sodium, articaine. * Vertical root fracture * External or internal root resorption * Periodontal pocket depth \>5 mm * Tooth mobility Grade II or III * Presence of periapical lesion (radiolucency)

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Conditions

The condition(s) this trial relates to.

pulpitis Toothache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Irreversible pulpitis (toothache)

Contacts and locations

Locations

  • Faculty of dentistry, Fayoum University

    Al Fayyum, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.