Which pill best eases root canal pain? new study puts three to the test
NCT ID NCT07204379
First seen Nov 01, 2025 · Last updated Jun 21, 2026 · Updated 34 times
Summary
This completed early-phase trial tested three oral painkillers—Novafen, Tramadol, and Naproxen—against a placebo (multivitamins) for pain after root canal treatment. 100 adults with tooth pain took one of the four options, and their pain was measured on a 0–10 scale. The goal was to see which drug provides the best relief after the procedure.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
-
AFID
Rawalpindi, Punjab Province, 54000, Pakistan
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Novafen, Tramadol, Naproxen
What this could lead to
If one painkiller works better, dentists may have a clearer choice for managing post-root-canal pain.
What could go wrong
This is a small, early-phase trial (100 people) comparing common drugs, so results may not apply to everyone or change practice significantly.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.