Root canal pain relief may depend on your DNA
NCT ID NCT07012382
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether a specific gene variation (SCN9A rs6746030) affects the success of numbing injections for root canal treatment. Researchers compared 200 patients with irreversible pulpitis who either had successful or failed anesthesia. By analyzing DNA from cheek swabs, they aimed to see if certain gene types are linked to poor numbing. The goal is to understand why some people don't get numb and potentially personalize dental pain management.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could help dentists predict who might not get numb from standard injections, leading to personalized anesthetic plans for root canal patients.
What could go wrong
This is a small, completed observational study, not a treatment trial. The findings may not apply to all patients or change clinical practice directly.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Faculty of Dentistry, Jamia Millia Islamia
New Delhi, New Delhi, 110025, India