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Can a different rinse cut pain after root treatment in kids?

NCT ID NCT07722416

Symptom relief Sponsor: TC Erciyes University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial compares two irrigation solutions used during regenerative endodontic treatment for immature permanent teeth with infection. Forty children aged 9 to 16 will receive either octenidine or EDTA as a rinse, and their pain levels will be tracked for a week. The goal is to see if one solution leads to less discomfort after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
0.1% octenidine dihydrochloride or 17% ethylenediaminetetraacetic acid (EDTA) as irrigation solutions
What this could lead to
If one solution reduces pain more, it could improve comfort for children undergoing this dental procedure.
What could go wrong
This is a small, early-stage trial with only 40 participants, so results may not apply to everyone. Pain is subjective and hard to measure precisely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Oct 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

8 to 16 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy status classified as American Society of Anesthesiologists class I; * An immature permanent tooth with pulp necrosis and apical periodontitis; * Cvek stage 2 or 3 root development; * Preoperative pain below 40 on a 0-100 numerical rating scale (NRS); * A baseline Periapical Index (PAI) score between 2 and 4; * A tooth considered restorable and suitable for RET; and * Willingness of the participant and legal representative to comply with postoperative assessment and follow-up requirements. Exclusion Criteria: * systemic disease * bruxism or another parafunctional habit * had used analgesics within 12 hours before treatment * severe root canal curvature * vertical root fracture

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Conditions

The condition(s) this trial relates to.

dental pulp disorder dental pulp necrosis Pain, Postoperative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Endodontic disease

Contacts and locations

Locations

  • Erciyes Üniversitesi Diş Hekimliği Fakültesi

    Kayseri, Kayseri, 38039, Turkey (Türkiye)

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