New pill combo may ease root canal pain without harsh drugs
NCT ID NCT06298383
First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times
Summary
This study tested whether taking a combination of trypsin, bromelain, and rutoside before a root canal helps the numbing shot work better and lowers pain after the procedure. 124 adults with painful tooth inflammation (pulpitis) took the medication or a placebo. The goal was to improve anesthesia success and reduce post-treatment pain using a gentler anti-inflammatory option.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SYMPTOMATIC IRREVERSIBLE PULPITIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Faculty of Dentistry, Cairo University
Cairo, 4450113, Egypt
-
Faculty of Oral and Dental Medicine, Egyptian Russian University
Cairo, Cairo Governorate, 11829, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a gentler root canal tool ease post-treatment pain?
- Could a simple injection make root canals less painful?
- Could a simple steroid shot make root canals less painful?
- Could a cold rinse during root canals ease Post-Procedure pain?
- Chill after the drill: could cold saline soothe root canal pain?
- Could a simple device make root canals less painful?