Dental fillings that soothe the tooth nerve? new trial tests bioactive materials
NCT ID NCT07715383
First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time
Summary
This trial compares different bioactive restorative materials and placement techniques to see how they affect the health of the tooth's pulp (nerve) after treating deep cavities. Researchers will measure inflammatory markers in the fluid around the tooth and track post-treatment pain. The goal is to identify which materials and methods best protect the pulp and reduce inflammation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- bioactive restorative materials (glass ionomer, resin-modified glass ionomer) placed using different techniques
- What this could lead to
- If successful, this could help dentists choose filling materials that better protect the tooth's nerve and reduce inflammation after treating deep cavities.
- What could go wrong
- This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. The study measures short-term markers, not long-term tooth survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
30 people
The number who actually took part.
- Started
-
Mar 2026
- Finished
-
Apr 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
21 to 50 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Simple occlusal deep carious lesions. * ICDAS 5 and 6. * No restorations with the related teeth. * Periodontally healthy patient (no bleeding on probing and no radiographic evidence of periodontal bone loss) * Normal occlusion. * Participants willing to commit for the entire period of the trial and agreed to sign the written consent after full explanation of the study. Exclusion Criteria: * Vulnerable groups such as pregnant females, breast feeding, prisoners, mentally ill, etc.… * Cigarette smoking or any form of tobacco consumption. * Medically compromised patients as diabetes. * A previously endo treated teeth. * Ongoing dental or periodontal treatment 12 months before the beginning of the study. * Presence of periodontal pockets \>3 mm in the affected tooth. * Antibiotics or any medication that might lead to decreased salivary flow.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Dental caries are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ain Shams University Hospitals
Cairo, Abbasia, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a squeezable filling match the standard for cavities?
- Could toothbrushing drills in schools cut childhood cavities?
- Can a silver solution replace the drill for tooth decay in cancer patients?
- Can a Zirconia-Enriched filling outlast standard materials for Kids' cavities?
- Could a VR headset replace the Dentist's drill of dread?
- Which filling fights cavity bacteria best in Kids' teeth?