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Can a silver solution replace the drill for tooth decay in cancer patients?

NCT ID NCT07803757

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

This trial compares two ways to treat tooth decay at the gum line in elderly cancer patients. One method uses a silver solution to stop decay without drilling, then places a filling. The other uses the traditional approach of drilling out the decay before filling. The study will follow patients for a year to see which fillings stay in place better, cause less discomfort, and are more satisfying to patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Silver diamine fluoride (SDF) with potassium iodide, followed by a glass ionomer filling, using a minimally invasive technique without drilling.
What this could lead to
If it works, this could offer a less painful, faster way to treat tooth decay in elderly cancer patients, reducing the need for drilling and improving comfort.
What could go wrong
The trial is small and early, so results may not apply to everyone. SDF can cause black staining on teeth, and the new method might not hold up as well as traditional fillings over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient-related criteria: * Adult cancer patients of both genders, aged 35-55 years * Good oral hygiene * Willing to sign the informed consent * Co-operative patients who accept the follow-up period Tooth-related criteria: * Teeth with primary root surface caries (active dentin carious lesions, Nyvad score 2 or 3) * Teeth with gum recession * Teeth vital according to pulp sensitivity tests * Controlled gingival or periodontal conditions Exclusion Criteria: * Patient-related criteria: * Allergy to any of the restorative materials * Patients undergoing orthodontic treatment with fixed appliances * Pregnant women * Patients who frequently use analgesics or any drugs that could mask pain Tooth-related criteria: * Teeth with previous restorations * Spontaneous or prolonged pain (more than 15 seconds) after cold test, indicating irreversible pulpitis * Negative sensibility test, periapical radiolucency, or sensitivity to percussion * Mobile teeth indicating periodontal disease or trauma * External or internal resorption * Chipped teeth or cuspal loss

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Conditions

The condition(s) this trial relates to.

dental caries root caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical caries Dental caries

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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