DENTAL CARIES

This study tests whether ozone therapy, followed by a remineralizing gel, can reverse the earliest stage of cavities in children aged 6-14. Half of the 80 participants will get ozone plus gel, the other half just gel. Researchers will check the teeth over 8 weeks using special li…

This study compares a new flexible white dental crown (BioFLX) to the standard stainless steel crown for treating cavities in baby molars. Researchers want to see if the white crown works just as well as the metal one in terms of gum health, plaque buildup, wear, and staying in p…

This study compares two methods for treating cavities in children's back molars: the Hall Technique, which places a crown over the tooth without drilling or numbing, and the conventional method, which requires drilling and anesthesia. Researchers will track 200 children aged 5-8 …

This study looks at two types of tooth-colored filling materials (ormocer and methacrylate-based bulk-fill) and different polishing methods for cavities near the gum line (class V). About 25 adults with these cavities will receive fillings and be followed for 2 years to see which…

This study tests a new type of dental filling called a bioactive bulk-fill composite for treating cavities in back teeth. Researchers will compare it to a standard filling in 34 adults, each receiving both types in similar cavities. The goal is to see if the new material improves…

This study compares two types of dental crowns: one made with a 3D printer and one made with a standard CAD-CAM machine. Twelve people with two damaged teeth will get one of each crown to see which performs better in terms of look, function, and gum health over two years. The goa…

This study tests whether a daily cream called MI Paste Plus can reduce cavity-causing bacteria and prevent white spots on teeth in people with braces. Two hundred participants will apply the cream nightly for three months. Researchers will measure bacteria levels and check for ne…

This study compares two methods of hardening a tooth-colored filling material in children's baby molars. One method uses a fast 5-second light, the other a standard longer light. Researchers want to see if the fast method works just as well and is as safe over 12 months. About 70…

This study tests a new type of dental filling that hardens on its own, compared to a standard filling that requires a special light. The goal is to see if the new filling is easier to place and works just as well for cavities between back teeth. About 50 adults aged 18-47 with ne…

This study tests whether a new material called PILP is safe to use when treating cavities in adults. Thirty participants will have PILP or a placebo applied to their tooth before getting a filling. They will be monitored for six months to check for tooth health, pain, and gum inf…

This study compares eggshell powder to Biodentine for treating tooth pulp exposure in children's baby molars. Thirty kids with deep cavities but no infection will get a pulpotomy, where the damaged pulp is removed and the material is placed. Researchers will check for pain, swell…

This study compares two ways to treat deep cavities in young permanent teeth without exposing the nerve. In selective excavation, the dentist removes only the outer decay and seals the tooth. In stepwise excavation, they place a temporary filling first and remove more decay a few…

This early study tests a new type of dental implant that uses the leftover ligament tissue from a pulled tooth to help the implant bond with the jawbone. Six adults needing a single tooth extraction will get the implant right away and be followed for 48 weeks. Researchers will ch…

This study tests whether a silver liquid (silver diamine fluoride) is better than standard fluoride varnish at reducing cavity-causing bacteria in children aged 3 to 8. Each child will get both treatments on different sides of their mouth. The goal is to see which one works bette…

This study follows 480 older adults (average age 74) from low-income housing to see which treatment better stops tooth decay over 3 to 6 years. One group gets a simple painted-on silver solution (SDF) twice a year; the other gets a standard filling plus fluoride varnish. Research…

This study compares three different tooth-colored onlay materials used to repair back teeth with deep cavities that extend below the gum line. Each of the 18 adult participants will receive three onlays made from different materials. Researchers will check the onlays at 2 weeks, …

This study tests whether computer analysis of 3D dental scans can accurately detect gum disease, gingivitis, and cavities, compared to traditional manual exams. About 30 adults with at least one gum recession will participate. If successful, this approach could make dental diagno…

This study is testing how well different digital tools—like special cameras, X-rays, and AI analysis—can find cavities compared to a standard dental exam. About 100 adults with cavities will be checked using these methods. The goal is to see which tools are most accurate so denti…

This study is testing whether a special intraoral scanner can accurately detect dental plaque and cavities, compared to standard methods like dye and X-rays. Researchers will scan the teeth of 50 adults aged 18 to 70 and compare the results to traditional plaque-disclosing agents…

This study will give thousands of elementary school students refillable water bottles and install hydration stations in their schools, along with lessons about healthy hydration. Researchers will track whether this simple change reduces tooth decay and helps maintain healthy body…

This study tests whether a probiotic spray containing good bacteria can help prevent and treat cavities in children. 130 kids aged 7-10 will use the spray or a placebo twice daily for 3 months. Researchers will check if it reduces harmful mouth bacteria and slows cavity growth.

This study will test whether applying fluoride varnish and placing special sealants can prevent and control cavities in 2,500 children aged 6 to 12. The treatments are minimally invasive and designed for use in public health settings. Children will be checked every three months f…

This study tests whether providing health education and helping mothers form supportive social networks can prevent dental cavities and unhealthy weight gain in their young children. About 460 Bangladeshi mothers and their children (ages 1-4) will take part. One group gets educat…

This study compares two numbing techniques for dental work in children aged 6 to 12: a computer-controlled injection into the jawbone (digital intraosseous) and a manual injection into the ligament around the tooth. Researchers will measure pain, heart rate, and how well the numb…

This study will compare two types of crowns—stainless steel and zirconia—placed on children's back baby teeth after pulp treatment. Ten healthy children aged 4 to 5 will receive both types of crowns, and researchers will check gum health, plaque buildup, tooth wear, and how satis…

This study looks at tooth decay and oral hygiene in children aged 7-12 with specific learning disabilities (SLD) and compares them to healthy children. Researchers will check teeth and gums, and ask about brushing and eating habits. The goal is to see if children with SLD have di…

This study looks at certain substances in the saliva of children aged 6-8 with and without cavities. Researchers will apply a fluoride varnish or a combination of fluoride and chlorhexidine (a germ-killing rinse) to see how these treatments change the saliva markers over one mont…

This study looks at whether archaea, a type of microbe, are involved in tooth decay. Researchers will collect saliva and cavity tissue samples from 200 adults to check for the presence and amount of archaea. The goal is to better understand what causes cavities and possibly find …

This study looks at how placing a special type of crown (Hall crown) on decayed baby molars changes the way children's teeth fit together. Researchers will measure tooth movements and bite contact areas in 60 children over one month using digital scans. The goal is to understand …

This study looks at whether training medical staff and using electronic health records can encourage older adults (55+) on Medicaid to visit the dentist more often. About 929 participants from 12 primary care clinics will be split into two groups: one where doctors get extra trai…

This study looks at a dental procedure called deep margin elevation (DME) for fixing cavities that go below the gum line. Researchers want to see if placing the filling slightly deeper than usual is safe for the gums and tooth nerve. They will treat 81 adults with deep cavities a…