DENTAL CARIES

This Phase 2 trial tests whether a topical drug called KH001 can preserve the pulp (nerve) inside teeth with deep cavities. Adults with deep dentinal caries will receive either KH001 or a placebo applied to the cavity. The study tracks how many people develop irreversible pulpiti…

This trial tests whether a one-bottle or a two-bottle HEMA-free dental adhesive works better for filling cavities on the front surfaces of teeth. About 50 adults with early to moderate cavities will receive a filling using one of the two adhesives. Researchers will check how well…

This study compares toothpaste tablets to a standard toothpaste (Colgate Cavity Protection) for cleaning teeth and gums. Fifty adults will use one of the two products for six weeks. Researchers will measure plaque, gum inflammation, and cavities before and after the trial to see …

This study investigates how bacteria that cause tooth decay and gum disease spread among family members. Researchers will treat either the child alone, the child and parents, or all family members with professional dental cleaning. They will track bacterial transmission using DNA…

This study compares 3D-printed resin crowns to standard stainless steel crowns for children's back teeth that have had pulp treatment. Twenty-six children aged 4 to 8 will receive one type of crown and be followed for a year. The goal is to see if the 3D-printed crowns lead to he…

This study compares two types of computer-designed and milled inlays—hard hybrid ceramic and resin composite—for repairing large cavities in vital back teeth. Fifty healthy adults aged 16 to 50 with a single molar needing a large filling will receive one of the two inlays. Resear…

This study tests whether applying a thin, clear surface sealant over tooth-colored fillings helps prevent discoloration and improves how long the filling lasts. Twenty-five adults with cavities in their back teeth will receive either a sealant or standard polishing. Researchers w…

This study looks at three types of dental cement used to attach zirconia crowns to young children's front teeth. About 120 healthy kids aged 2 to 7 with decayed or injured teeth will get crowns and be checked for up to 3 years. The goal is to see which cement holds the crown best…

This study compares three types of dental fillings—bioactive, nanohybrid, and bulk-fill—for treating cavities between teeth. Sixty adults with at least three cavities will receive each type of filling and be monitored for up to four years. The goal is to see which material holds …

This study will test a new injectable tooth filling material against a standard one for fixing cavities between baby molars in children aged 3 to 8. Fifty kids will get one of the two fillings, and dentists will check how well they hold up over a year. The goal is to see which fi…

This study will compare two treatments for cavities in children's back baby teeth. One uses a new injectable bioactive filling material, and the other uses the Hall Technique (placing a metal crown without drilling). About 50 children aged 3-8 with moderate cavities will be follo…

This study tests whether using plaque-disclosing dyes (like erythrosine) with a special light can kill more cavity-causing bacteria in children aged 3 to 7 years. Seventy-two kids at high risk for cavities will get either standard dental cleaning or cleaning plus the dye-and-ligh…

This study will compare Bioflx crowns (a newer, tooth-colored material) with standard stainless steel crowns for children aged 6 to 9 who have had pulp treatment on their back baby teeth. The goal is to see how each crown affects bite force and the space between teeth, and how sa…

This study will test four different dental filling materials in 92 children aged 4-8 who have cavities in their baby molars. The fillings include newer materials like Cention N and Stela, as well as standard options like Beautifil II and resin-modified glass ionomer. Researchers …

This study will test whether 3D-printed fillings work as well as standard bulk-filled resin ones for large cavities in back teeth. About 50 adults aged 22 to 45 with deep decay in a molar will receive one of the two filling types. Researchers will check the fillings' strength, fi…

This study tests different sequences of minimally invasive dental treatments—like silver diamine fluoride, sealants, and fluoride varnish—plus a hygiene program, to see which works best for children aged 5 to 13 in schools. The goal is to reduce the number of kids who don't respo…

This study looks at how well a new type of dental filling (bioactive restorative system) works in people with controlled diabetes compared to those without diabetes. Fifty adults needing a filling in a back tooth will be followed for 18 months. Researchers will check for discolor…

This study tests whether a mouthwash made from moringa leaves can reduce dental plaque, bacteria, and early cavities as well as the standard chlorhexidine rinse. Researchers will enroll 90 adults with mild gum inflammation and moderate-to-high cavity risk. Participants will use e…

This study compares a new, easier-to-use tooth-colored filling material to a standard one for cavities between back teeth. Fifty adults aged 18-64 with cavities will receive one of the two fillings and be checked after 12 months for how well they hold up, look, and feel. The goal…

This study looks at how different 3D-printed materials affect gum health and restoration success in teeth with deep cavities that need margin elevation. Researchers will treat 48 patients and check their teeth at 6 and 12 months using dental and gum health scores. The goal is to …

This study tests whether a special silver liquid (silver diamine fluoride) can stop tooth decay in elderly people living in nursing homes. Sixty participants will either get the silver treatment or a placebo, and their teeth will be checked after 6 and 12 months. The goal is to i…

This study will check if smartphone photos, 3D dental scans, and a special fluorescent light can accurately detect early cavities in people who have finished braces. Thirty participants aged 11 to 46 with early white spots on their teeth will be followed for three months. Researc…

This trial tests whether sending oral health tips via WhatsApp to mothers, in addition to standard face-to-face advice, improves their knowledge and their children's toothbrushing habits. Mothers of children aged 3 to 6 will receive either usual education alone or with 16 additio…

This trial tests whether swabbing toddlers' teeth with povidone iodine can prevent tooth decay and reduce cavity-causing mouth germs. Children aged 1 to 3 will have their teeth swabbed weekly for the first month and then monthly, with some also receiving a daily probiotic. The st…

This trial tests whether cleaning the chewing surfaces of children's teeth with a fine erythritol powder spray (Guided Biofilm Therapy) before applying a protective sealant helps the sealant stay in place longer than the standard rotary-brush polishing. Each child aged 6–10 will …

This study tests whether applying povidone iodine (a disinfectant) to toddlers' teeth before fluoride varnish prevents cavities better than fluoride varnish alone. About 393 children aged 6-24 months with healthy teeth or early white spots will be followed to see which approach r…

This study tests if using a diode laser before applying a tooth-colored sealant helps it stick longer and prevent cavities better. About 111 young adults aged 17-22 will get sealants on their back teeth, with or without laser pre-treatment. Researchers will check sealant retentio…

This trial asks whether a newer 'bulk-fill' composite filling causes less tooth sensitivity after cavity repair than the traditional layer-by-layer method. Dentists often apply standard fillings in thin layers to avoid shrinkage gaps, but bulk-fill materials can be placed in thic…

This study compares different numbing methods to reduce pain during dental cavity treatment. About 204 adults with tooth decay will receive either a light-based device, a numbing gel, or a placebo before local anesthesia. Researchers will measure pain during and after the procedu…

This study compares a single-shade flowable composite resin to a multi-shade composite for filling cavities in back teeth. Thirty adults with at least four cavities will receive both types of fillings and be followed for five years. Researchers will check how well the fillings ma…

This study tests whether applying Gluma desensitizer before a filling can reduce tooth sensitivity afterward. Sixty adults with cavities in their back teeth will be randomly assigned to get either the desensitizer plus a standard filling or just the standard filling. Their pain r…

This study aims to find biological markers in saliva, mouth rinse, blood, or tissue that could help identify and predict the course of oral cancer, gum disease, and tooth decay. Researchers will collect health information and samples from 4,000 adults with these conditions and he…

This study looks at how common cavities are in the first permanent molars of 6- to 7-year-old Egyptian children and whether diet and tooth-brushing habits play a role. Researchers will examine 272 children's teeth and ask parents about their child's eating and oral hygiene routin…

This study looks at saliva from people with osteoporosis to measure certain immune markers and an enzyme called MMP-8. Researchers also check participants' dental cavities. The goal is to better understand how osteoporosis might affect oral health. No treatments are given—only sa…

This study looks at how well 3D-printed resin fillings hold up in back teeth with large cavities. Researchers will compare two different ways of shaping the tooth before placing the filling. Fifty adults will be followed for 18 months to see which design leads to fewer cracks or …

This study follows 400 obese adults in Norway to see how weight loss from lifestyle changes, medication, or surgery affects their oral health. Researchers will measure gum disease, cavities, and tooth erosion before and after weight loss. The goal is to understand the link betwee…

This study looks at how stainless steel crowns placed on weak permanent molars (due to a condition called MIH) affect a child's bite and jaw function. Forty-six children will have their teeth scanned before, right after, and up to 3 months after crown placement. The goal is to un…

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…

This study looks at how two types of dental cement used to attach stainless steel crowns affect gum health in 45 children aged 6-10. Researchers measured gum inflammation and certain immune markers before and one week after placing the crowns. The goal is to see if one cement cau…

This study looks at how well a special type of dental filling called Giomer works in people with and without diabetes. Researchers will place fillings in cavities on the tooth neck and check them over 18 months to see if they stay in place and prevent new decay. The goal is to un…

This study looks at whether sending short dental health videos through WhatsApp can improve how much 10-12 year old children in Cairo know about taking care of their teeth, and whether it changes their brushing and eating habits. About 150 children will take part, with one group …

This study looks at 58 children with deep cavities in their baby molars. Dentists will perform a pulpotomy (removing the infected nerve and sealing the tooth) and measure levels of cytokines—substances that signal inflammation—in the pulp. The goal is to see if these levels can p…