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Could a gentler cleaning method make cavity sealants last longer?

NCT ID NCT07725133

Prevention Sponsor: Marmara University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests whether cleaning the chewing surfaces of children's teeth with a fine erythritol powder spray (Guided Biofilm Therapy) before applying a protective sealant helps the sealant stay in place longer than the standard rotary-brush polishing. Each child aged 6–10 will receive both methods on opposite sides of the mouth, and the sealants will be checked over three years. The goal is to see which cleaning approach leads to better sealant retention and fewer cavities.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Guided Biofilm Therapy with erythritol powder vs. conventional rotary-brush polishing, both followed by resin-based pit and fissure sealant
What this could lead to
If one cleaning method proves better, it could improve how long dental sealants last, offering better cavity prevention for children.
What could go wrong
This is a small, early-stage trial in one university. Results may not apply to all children or dental settings, and both methods already have some evidence behind them.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Oct 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 10 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children aged 6-10 years presenting to the Department of Pediatric Dentistry, Marmara University Faculty of Dentistry, for routine dental treatment. * Systemically healthy individuals classified as ASA I. * Children who are cooperative and able to maintain communication throughout the clinical procedure. * Presence of at least two comparable permanent first molars with unrestored occlusal surfaces that are either caries-free or have initial lesions limited to the pit and fissure level. Exclusion Criteria: * Individuals with systemic diseases (e.g., diabetes, epilepsy, cardiovascular diseases), classified as ASA II or higher. Individuals who have used antibiotics, anti-inflammatory drugs, or immunosuppressive medications within the past 3 months. * Children who are unable to communicate due to emotional, psychological, or developmental disorders. * Individuals with previously placed pit and fissure sealants on their permanent first molars. * Presence of deep carious lesions, restorations, or structural defects such as molar-incisor hypomineralization (MIH) in the teeth planned for inclusion in the study.

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Conditions

The condition(s) this trial relates to.

dental caries van der Woude syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries Pit and fissure sealant retention

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Marmara University

    Istanbul, Maltepe, 34384, Turkey (Türkiye)

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