A new topical treatment may spare teeth from root canals

NCT ID NCT07751016

Not yet recruiting Disease control Sponsor: Seoul National University Dental Hospital Source: ClinicalTrials.gov ↗

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This Phase 2 trial tests whether a topical drug called KH001 can preserve the pulp (nerve) inside teeth with deep cavities. Adults with deep dentinal caries will receive either KH001 or a placebo applied to the cavity. The study tracks how many people develop irreversible pulpitis or pulp necrosis, and whether the dentin thickens, to see if KH001 can avoid the need for more invasive treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: KH001, a topical drug applied to deep cavities
What this could lead to: If successful, KH001 could offer a way to treat deep cavities without needing root canals, preserving natural teeth.
What could go wrong: This is an early-stage trial with only 36 participants, so results may not apply broadly. The drug could also cause allergic reactions or fail to prevent pulp damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dental caries dentin caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DENTAL CARIES

Contacts and locations

Locations

Seoul National University Dental Hospital

Seoul, South Korea

More trials for these conditions

Other studies related to the condition(s) this trial covers.