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Pre-Dental painkiller may boost numbing power for root canals

NCT ID NCT05927922

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study tests whether taking ibuprofen before a root canal can improve the effectiveness of local anesthesia in people with severe tooth inflammation (irreversible pulpitis). Participants will receive either ibuprofen or a placebo before the procedure, and pain levels will be measured during treatment. The goal is to see if the painkiller helps make the numbing injections work better and reduces discomfort.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ibuprofen
What this could lead to
If it works, this could point toward a simple way to make dental procedures less painful for people with inflamed teeth.
What could go wrong
This is a small early-phase study, so results may not apply to everyone. Ibuprofen may not improve anesthesia for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

48 people

The number who actually took part.

Started

Jun 2023

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Males or females with age between 18-50 years. 2. Systemically healthy patients (ASA I or II). 3. patient's signs and symptoms give diagnosis of symptomatic irreversible pulpitis in mandibular molar teeth including: i. Presence of sharp pain upon thermal stimulus, lingering pain (often 30 seconds or longer after stimulus removal), spontaneity (unprovoked pain) and referred pain (According to American Association of Endodontics, 2013). According to Azim et al (2022), a clinical diagnosis for symptomatic irreversible pulpitis based on subjective (lingering pain to thermal changes for extended period). ii. Pre-operative sharp pain marked on VAS scale by reading not less than 6. iii. exaggerated response with continuous lingering pain to cold pulp tester using ethyl chloride spray (Walter Ritter Gmbh +Co.-pharmaceutical - Germany. The Egyptian pharmaceutical trading company) and electric pulp tester (Denjoy dental CO., LTD.Changsha.P.R China). iv. Normal periapical radiographic appearance or slight widening of the periodontal ligament space. v.Presence of objective findings such as caries or fracture, deep restorations. vi. No pain on percussion. \- Exclusion Criteria: 1. Allergy to articaine or Ibuprofen 2. History of intolerance to NSAIDs. 3. Patients who have taken analgesics or anti-inflammatory drugs 12 hours before treatment. 4. Patients with two or more adjacent teeth requiring endodontic treatment. 5. Pregnant or nursing females. 6. Teeth that have periodontal affection (with a pocket depth greater than 5mm, associated with swelling or fistulous tract, or greater than grade I mobility) 7. Non-restorable teeth. 8. Teeth fracture and resorption.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mandibular molar teeth with symptomatic irreversible pulpitis

Contacts and locations

Locations

  • faculty of dentistry Cairo university

    Cairo, Cairo Governorate, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.