Dental pain breakthrough? pills before needle may boost numbing

NCT ID NCT07146997

Completed Symptom relief Sponsor: Zahoor khan Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether taking ibuprofen and serratiopeptidase before a dental numbing shot helps it work better for people with severe tooth pain from pulpitis. 96 adults were split into four groups: placebo, ibuprofen alone, serratiopeptidase alone, or both. Pain was measured during drilling and root canal steps. The goal is to see if the combination improves numbing success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ibuprofen and serratiopeptidase
What this could lead to: If successful, this combination could make dental numbing more reliable for people with severe tooth inflammation, reducing pain during root canal treatment.
What could go wrong: This is a small, completed study. Results may not apply to all patients, and the effect might be modest. Risks include side effects from the medications.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYMPTOMATIC IRREVERSIBLE PULPITIS

Contacts and locations

Locations

HITEC-IMS Taxila

Rawalpindi, Punjab Province, 47080, Pakistan

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