Dental pain breakthrough? pills before needle may boost numbing
NCT ID NCT07146997
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether taking ibuprofen and serratiopeptidase before a dental numbing shot helps it work better for people with severe tooth pain from pulpitis. 96 adults were split into four groups: placebo, ibuprofen alone, serratiopeptidase alone, or both. Pain was measured during drilling and root canal steps. The goal is to see if the combination improves numbing success.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ibuprofen and serratiopeptidase
What this could lead to
If successful, this combination could make dental numbing more reliable for people with severe tooth inflammation, reducing pain during root canal treatment.
What could go wrong
This is a small, completed study. Results may not apply to all patients, and the effect might be modest. Risks include side effects from the medications.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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HITEC-IMS Taxila
Rawalpindi, Punjab Province, 47080, Pakistan