Dentists test three common irrigants to ease root canal pain

NCT ID NCT07486245

Completed Symptom relief Sponsor: CMH Multan Institute of Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested three different rinses used during root canal treatment to see which one causes the least pain afterward. Ninety adults with tooth pain took part, and each received one of the rinses: sodium hypochlorite, hydrogen peroxide, or normal saline. Pain levels were measured after the procedure to help dentists choose the best option for patient comfort.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sodium hypochlorite 2.5%, hydrogen peroxide 3%, and normal saline
What this could lead to: If successful, this study could help dentists choose the most comfortable root canal irrigant, reducing pain and stress for patients.
What could go wrong: This is a small, completed study with 90 participants, so results may not apply to everyone. Pain is subjective and can vary widely between individuals.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PULPITIS POST ENDODONTIC PAIN

Contacts and locations

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Locations

CMH Multan

Multan Khurd, Pakistan

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