Can tiny silver particles supercharge root canal healing?
NCT ID NCT07762599
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This trial tests whether adding silver nanoparticles to a standard antibiotic paste used inside root canals can better reduce pain and inflammation in people with symptomatic apical periodontitis, a painful infection at the tooth root. Half of the 50 adult participants receive the standard paste, while the other half gets the silver-enhanced version. Researchers measure pain levels and inflammatory markers in the gum fluid before and after treatment, and check bone healing at 3 and 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Silver nanoparticle reinforced double antibiotic paste
- What this could lead to
- If effective, this paste could offer a more powerful way to disinfect root canals, reducing pain and speeding healing after treatment.
- What could go wrong
- This is a small, early-stage trial with only 50 participants. The added silver may not improve outcomes, and safety or long-term effects are not yet fully known.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
All India Institute of Medical Sciences
Nagpur, Maharashtra, 441108, India
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