Can tiny silver particles supercharge root canal healing?

NCT ID NCT07762599

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial tests whether adding silver nanoparticles to a standard antibiotic paste used inside root canals can better reduce pain and inflammation in people with symptomatic apical periodontitis, a painful infection at the tooth root. Half of the 50 adult participants receive the standard paste, while the other half gets the silver-enhanced version. Researchers measure pain levels and inflammatory markers in the gum fluid before and after treatment, and check bone healing at 3 and 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Silver nanoparticle reinforced double antibiotic paste
What this could lead to
If effective, this paste could offer a more powerful way to disinfect root canals, reducing pain and speeding healing after treatment.
What could go wrong
This is a small, early-stage trial with only 50 participants. The added silver may not improve outcomes, and safety or long-term effects are not yet fully known.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • All India Institute of Medical Sciences

    Nagpur, Maharashtra, 441108, India

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Other studies related to the condition(s) this trial covers.