Can regenerating tooth tissue beat root canals for healing dental infections?
NCT ID NCT07700394
First seen Jul 14, 2026 · Last updated Jul 16, 2026 · Updated 2 times
Summary
This trial compares three treatments for mature teeth with apical periodontitis (infection at the root tip): standard root canal treatment, regenerative endodontic treatment using a blood clot, and regenerative treatment with added bone-growth proteins. The study includes 30 healthy adults aged 18-30 with infected molars. Healing is measured by changes in lesion size on 3D X-rays.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- regenerative endodontic treatment using a blood clot scaffold, with or without recombinant human BMPs (rhBMPs)
- What this could lead to
- If successful, regenerative treatments could offer a more biological approach to healing dental infections, potentially preserving more natural tooth structure.
- What could go wrong
- This is a small, early-stage trial with only 30 participants, so results may not apply broadly. Regenerative techniques are still experimental and may not heal as reliably as standard treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Faculty of dentistry ain shams university
Cairo, Egypt
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