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Can regenerating tooth tissue beat root canals for healing dental infections?

NCT ID NCT07700394

Disease control Sponsor: Sara Tariq Elemam Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 14, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This trial compares three treatments for mature teeth with apical periodontitis (infection at the root tip): standard root canal treatment, regenerative endodontic treatment using a blood clot, and regenerative treatment with added bone-growth proteins. The study includes 30 healthy adults aged 18-30 with infected molars. Healing is measured by changes in lesion size on 3D X-rays.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
regenerative endodontic treatment using a blood clot scaffold, with or without recombinant human BMPs (rhBMPs)
What this could lead to
If successful, regenerative treatments could offer a more biological approach to healing dental infections, potentially preserving more natural tooth structure.
What could go wrong
This is a small, early-stage trial with only 30 participants, so results may not apply broadly. Regenerative techniques are still experimental and may not heal as reliably as standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Dec 2021

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-30 years * Healthy patients with no systemic diseases or known allergic reactions * Mature permanent molars diagnosed with pulp necrosis * Presence of a medium sized periapical lesion confirmed clinically and radiographically (PAI=3,4,5) Exclusion Criteria: * Patients with generalized chronic periodontitis * Presence of small periapical lesions (PAI=1,2) * Periodontal pockets \> 3 mm * Presence of systemic diseases or known hypersensitivity to any material used in the study

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis

Contacts and locations

Locations

  • Faculty of dentistry ain shams university

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.