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Which root canal filling hurts less? a trial puts three sealers to the test

NCT ID NCT07767084

Symptom relief Sponsor: Minia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time

Summary

This trial investigates whether the type of sealer used during a root canal affects pain after the procedure. It will compare three different sealers—calcium hydroxide-based, bioceramic, and resin-based—in people with single-rooted teeth needing root canal treatment. Participants will rate their pain at several time points over a week to see if one sealer leads to less discomfort and less need for pain medication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Three different root canal sealers: calcium hydroxide-based, calcium silicate-based (bioceramic), and epoxy resin-based
What this could lead to
If one sealer proves better, it could guide dentists to choose materials that reduce post-root-canal pain and the need for painkillers.
What could go wrong
This is a small, early-stage study, so results may not apply to all patients. Pain is subjective, and individual responses can vary widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 66 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients requiring primary root canal treatment. * Patients with acute irreversible pulpitis. * Patients in good general health Exclusion Criteria: * Patients with systemic diseases affecting pain perception or healing. * Patients who had taken analgesics or antibiotics within 12-24 hours prior to treatment. * Pregnant or lactating women. * Previously treated teeth or teeth with root resorption, fractures, or severe periodontal disease

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post endodontic pain

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Endodontics Department Faculty of Dentistry

    RECRUITING

    Minya, Egypt

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