Root canal pain relief: does adding NSAIDs to paracetamol help?

NCT ID NCT02417337

Completed Symptom relief Sponsor: University of Khartoum Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol alone for easing post-treatment pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Paracetamol (acetaminophen) and non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen, mefenamic acid, and diclofenac
What this could lead to: If successful, this could point toward a more effective pain relief strategy after root canal treatment, reducing the need for stronger medications.
What could go wrong: This is a small, completed Phase 2 trial, so results may not apply to all patients. Combining drugs can increase side effects, and the study did not test long-term outcomes.

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Conditions

The condition(s) this trial relates to.

Pain Pain, Postoperative pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IRREVERSIBLE PULPITIS PAIN POSTOPERATIVE PAIN

Contacts and locations

Locations

University of Khartoum, Faculty of Dentistry,

Khartoum, 111-11, Sudan

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