Root canal pain relief: does adding NSAIDs to paracetamol help?
NCT ID NCT02417337
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol alone for easing post-treatment pain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Paracetamol (acetaminophen) and non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen, mefenamic acid, and diclofenac
What this could lead to
If successful, this could point toward a more effective pain relief strategy after root canal treatment, reducing the need for stronger medications.
What could go wrong
This is a small, completed Phase 2 trial, so results may not apply to all patients. Combining drugs can increase side effects, and the study did not test long-term outcomes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Khartoum, Faculty of Dentistry,
Khartoum, 111-11, Sudan