Magnesium boost for knee surgery pain relief?
NCT ID NCT06520475
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding magnesium to the anesthetic bupivacaine for a nerve block around the knee provides better pain relief after total knee replacement surgery. 94 adults undergoing knee replacement were randomly assigned to receive either bupivacaine with magnesium or bupivacaine alone. The goal was to see if the combination reduces pain scores, delays the first request for additional pain medication, and lowers opioid use.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bupivacaine and magnesium sulfate
What this could lead to
If adding magnesium works better than bupivacaine alone, it could offer longer-lasting pain relief after knee replacement surgery and reduce the need for strong painkillers.
What could go wrong
This is a small, completed study with only 94 participants. The results may not apply to all patients, and magnesium could cause side effects like low blood pressure or muscle weakness.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Kasr Alaini hospital
Cairo, Egypt