New shot could cut opioid use after bunion surgery

NCT ID NCT05831449

Completed Symptom relief Sponsor: Cali Pharmaceuticals LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental long-acting local anesthetic called CPL-01 in 616 people having bunion surgery. The goal was to see if it reduces pain and the need for opioid painkillers after the operation compared to a standard anesthetic or a placebo. Participants received the injection during surgery and were monitored for pain levels and any rescue medication use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CPL-01 (long-acting ropivacaine local anesthetic injection)
What this could lead to: If it works, CPL-01 could provide longer-lasting pain relief after foot surgery and reduce the need for opioid painkillers.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The drug may not prove significantly better than existing anesthetics or placebo, and individual responses to pain medication vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Bunion Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BUNION POST-OPERATIVE PAIN

Contacts and locations

Locations

Todd Bertoch

Salt Lake City, Utah, 84101, United States

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