Drug combo may stop opioids from making pain worse after surgery
NCT ID NCT01594047
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving ketamine during surgery and methadone after surgery can prevent a condition called opioid-induced hyperalgesia, where painkillers actually make pain worse. 113 patients having open colorectal surgery took part. Researchers measured the area of increased pain sensitivity around the surgical wound and pain levels using a 0-10 scale.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ketamine and methadone
- What this could lead to
- If successful, this approach could help reduce pain and the need for strong painkillers after surgery.
- What could go wrong
- This is a small, completed study. Results may not apply to all surgeries or patients. Ketamine and methadone have side effects like drowsiness and nausea.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, 20133, Italy
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