Can a common cough drug dampen pain sensitivity?

NCT ID NCT02596360

Completed Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This early-stage trial asks whether dextromethorphan, a common cough suppressant, can reduce heightened pain sensitivity in healthy adults. Participants receive both dextromethorphan and a placebo on separate occasions, and researchers measure pain thresholds in skin areas that become sensitized after a mild experimental pain procedure. The goal is to see if the drug can block the amplification of pain signals, which could inform future treatments for chronic pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dextromethorphan (Pulmodexane® 30mg)
What this could lead to: If dextromethorphan reduces pain sensitivity in healthy people, it could point toward new treatments for chronic pain conditions involving central sensitization.
What could go wrong: This is a small, early-phase study in healthy volunteers, so results may not apply to people with pain conditions. Dextromethorphan can cause side effects like dizziness and drowsiness.

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Conditions

The condition(s) this trial relates to.

Hyperalgesia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXPERIMENTAL PAIN HYPERALGESIA

Contacts and locations

Locations

CHU Clermont-Ferrand

Clermont-Ferrand, 63003, France

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