Can a pinch of naloxone stop painkillers from backfiring?
NCT ID NCT03066739
First seen Jun 16, 2026 · Last updated Jun 22, 2026 · Updated 2 times
Summary
This study tested whether adding an ultra-low dose of naloxone to a strong opioid (remifentanil) could prevent the increased pain sensitivity that sometimes happens after surgery. The trial included 8 adults undergoing spinal fusion surgery. The approach was to compare three different doses of remifentanil, with or without naloxone, but the study was terminated early, so results are limited.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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UC Irvine Medical Center
Orange, California, 92868, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ultra-low dose naloxone combined with remifentanil
What this could lead to
If it works, this could point toward a way to prevent increased pain sensitivity after surgery using opioids.
What could go wrong
This was a very small, terminated Phase 2 trial with only 8 participants, so results are not reliable. It is unclear if the approach works or is safe.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.