Could a seizure drug ease pancreatitis pain and reduce opioid side effects?
NCT ID NCT05603702
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual opioid medication. The main goals are to check for serious side effects and see if the drug is tolerable, with a secondary look at whether it reduces pain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lacosamide (also known as VIMPAT)
What this could lead to
If this trial succeeds, it could point toward a new way to manage chronic abdominal pain in pancreatitis patients while reducing the pain caused by long-term opioid use.
What could go wrong
This is a very early, small phase 1 trial with only 21 participants. It is designed mainly to test safety and tolerability, not effectiveness. The results may not apply to all patients, and the drug may cause side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Indiana University
Indianapolis, Indiana, 46202, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Ohio State University
Columbus, Ohio, 43210, United States
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Stanford University
Stanford, California, 94305, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States