Could a seizure drug ease pancreatitis pain and reduce opioid side effects?

NCT ID NCT05603702

Ongoing Symptom relief Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual opioid medication. The main goals are to check for serious side effects and see if the drug is tolerable, with a secondary look at whether it reduces pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lacosamide (also known as VIMPAT)
What this could lead to: If this trial succeeds, it could point toward a new way to manage chronic abdominal pain in pancreatitis patients while reducing the pain caused by long-term opioid use.
What could go wrong: This is a very early, small phase 1 trial with only 21 participants. It is designed mainly to test safety and tolerability, not effectiveness. The results may not apply to all patients, and the drug may cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome chronic pancreatitis Digestive System Diseases Hyperalgesia opiate dependence Pain pancreas disorder pancreatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC ABDOMINAL PAIN CHRONIC PAIN CHRONIC PAIN SYNDROME CHRONIC PANCREATITIS ERCP HYPERALGESIA OPIOID DEPENDENCE OPIOID-RELATED DISORDERS OPIOID-USE DISORDER PANCREATIC SURGERY

Contacts and locations

Locations

Indiana University

Indianapolis, Indiana, 46202, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Ohio State University

Columbus, Ohio, 43210, United States
Stanford University

Stanford, California, 94305, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States

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