Pancreatitis

This phase 3 trial tests a drug called plozasiran in 288 adults with severe hypertriglyceridemia (very high blood fats) who have had at least two pancreatitis attacks. Participants receive either the drug or a placebo every three months. The main goal is to see if the drug can pr…

This study tests a freezing device called a cryoprobe to remove dead tissue from the pancreas in people with a serious complication of acute pancreatitis. Instead of using standard tools like forceps or snares, the cryoprobe freezes the dead tissue so it can be pulled out more ea…

This study tests a drug called CM4620 in children and young adults who develop pancreatitis (inflammation of the pancreas) from a chemotherapy drug called asparaginase. The goal is to see if CM4620 is safe and can prevent severe complications like pancreatic cysts or tissue death…

This Phase 2 trial tests two experimental injections, HRS-7249 and SHR-1918, in 108 adults with severely high triglycerides who are at high risk of acute pancreatitis. The study aims to see if these drugs can safely lower fat levels in the blood and reduce the chance of a pancrea…

This study tests a single injection of a drug called RABI-767, given through a scope into the area around the pancreas, for people with predicted severe acute pancreatitis. About 36 participants will be randomly assigned to get the drug plus standard care or standard care alone. …

This study tests whether placing a small plastic tube (stent) in the pancreas during a gallstone removal procedure can prevent pancreatitis, a painful inflammation. 88 adults with both gallbladder and common bile duct stones will be randomly assigned to receive either standard ca…

This study tests a device called RELiZORB that adds digestive enzymes directly to liquid food given through a feeding tube. It is for people who have trouble digesting food after pancreatitis. The goal is to see if it improves symptoms and quality of life. About 60 adults will ta…

This phase 3 trial tests whether taking pancreatic enzyme capsules can help people who have lost significant weight after a severe bout of pancreatitis. The study will enroll 140 adults with more than 50% pancreatic damage and at least 5% weight loss. Participants will receive ei…

This study tests whether adding a person's own bone marrow stem cells to their islet transplant can help the islets survive longer and work better. It includes 42 adults with chronic pancreatitis who are already scheduled for pancreas removal and islet auto-transplant. Participan…

This study tests a device called Efferon LPS that filters toxins and inflammatory substances from the blood. It is being given to 150 people with severe acute pancreatitis within 24 hours of ICU admission. The goal is to see if it reduces organ failure and improves outcomes compa…

This study tests two diabetes medications, pioglitazone and empagliflozin, to see which one better controls blood sugar in people whose diabetes is caused by chronic or recurrent acute pancreatitis. About 40 adults aged 18-80 with this type of diabetes will take one of the drugs,…

This study tests whether placing a tiny plastic tube (stent) in the pancreas can lower the chance of pancreatitis after a difficult bile duct procedure called ERCP. About 268 adults who need this procedure will be randomly assigned to get the stent or not. The main goal is to see…

This study tests whether a short course of the steroid hydrocortisone can reduce inflammation and improve outcomes for people with severe pancreatitis. Researchers will give the drug or a placebo to 86 ICU patients and track their organ failure scores and hospital stay length. Th…

This study compares early versus delayed endoscopic drainage in patients with infected necrotizing pancreatitis. About 104 adults with symptomatic, infected pancreatic fluid collections will be randomly assigned to receive the procedure within 4 weeks of disease onset or after th…

This early-stage trial tests a single infusion of CS-121, a gene editing therapy, in 15 adults with familial chylomicronemia syndrome (FCS), a rare condition causing extremely high blood fat levels. The therapy targets the APOC3 gene to lower triglycerides and reduce disease burd…

This study compares a new device called Endorotor to standard methods for removing dead pancreatic tissue in patients with severe pancreatitis. About 64 adults who need this procedure will be randomly assigned to one of two groups. The goal is to see if the Endorotor clears the t…

This trial compares removing a metal stent at 2 weeks (with a plastic stent placed) versus the usual 4 weeks (without a plastic stent) in adults with walled-off pancreatic necrosis. The goal is to see if earlier removal lowers the chance of fluid collections coming back or needin…

This early-stage trial tests a new gene-editing treatment called CS-121 in 15 children and teens (ages 4-18) with a rare condition causing extremely high triglycerides. The therapy uses lipid nanoparticles to deliver a base editor that targets the APOC3 gene in the liver. The mai…

This study is testing whether taking pancreatic enzyme supplements (Creon) can improve blood sugar control and digestive function in people with chronic pancreatitis who have trouble digesting food. Researchers will monitor 80 participants over time to see how their glucose level…

This trial tests whether giving three treatments together—two medicines and a surgical patch—can lower the risk of major complications after Whipple surgery for pancreatic cancer and other tumors. The study includes 400 high-risk patients with a small pancreatic duct. If successf…

This study tests a drug called pirfenidone, currently used for lung disease, to see if it can safely reduce repeat attacks of pancreatitis. About 60 adults who have had two or more pancreatitis episodes will receive either the drug or a placebo. The goal is to lower the number an…

This trial looks at whether removing the gallbladder early (during the same hospital stay) or waiting 4 weeks after recovery is better for people with severe pancreatitis caused by gallstones. About 134 adults will be randomly assigned to one of the two timing options. The main g…

This study tests whether transplanting healthy gut bacteria (FMT) can reduce infections in people with moderate to severe acute pancreatitis. 80 participants will receive either FMT or a placebo through a feeding tube for five days. The goal is to see if FMT lowers the risk of se…

This study tests whether a single infusion of infliximab, a drug used for arthritis and Crohn's disease, can reduce inflammation in adults with acute pancreatitis. About 290 participants will receive either a low dose, a high dose, or a placebo. The main goal is to see if inflixi…

This study is testing a mixed meal test to better diagnose a specific type of diabetes (type 3c) that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and one of these pancreatic conditio…

This study is testing a new scoring system called OC26 to help doctors more accurately diagnose autoimmune pancreatitis, a condition where the immune system attacks the pancreas. Researchers will review medical data from 82 adults suspected of having the disease. If the OC26 crit…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study aims to develop a non-invasive breath test to detect pancreatic cancer earlier. Pancreatic cancer is often diagnosed late because early symptoms are vague. The test measures tiny molecules in breath that may signal cancer. Researchers will collect breath and urine samp…

This study is testing a software called Lipidica that analyzes fats in the blood to help screen for pancreatic cancer. Researchers will compare results from people with pancreatic cancer to those at high risk (due to family history or genetic factors) to see if the software can t…

This study tests a new blood test (Malabsorption Blood Test, or MBT) to find mild-to-moderate pancreatic insufficiency in people with chronic or recurrent acute pancreatitis. A small group of participants who respond to pancreatic enzyme replacement therapy (PERT) will then be ra…

This study looks at whether a urine test can quickly detect pancreatitis after pancreas removal surgery. About 50 adults having elective pancreatectomy will provide urine samples before, during, and after surgery. The results will be compared with standard blood tests to see if t…

This study tests an artificial intelligence (AI) system that analyzes contrast-enhanced CT scans to help diagnose and manage pancreatic diseases. The AI will classify patients into three groups: needing immediate treatment, close monitoring, or routine follow-up. Researchers will…

This Phase 3 study is testing whether markers in pancreatic fluid and blood can detect early pancreas cancer in people with high genetic risk. Participants receive a secretin injection to collect fluid during an endoscopy. The goal is to improve early detection in those with here…

This study compares two rectal non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and diclofenac, to see which one better prevents pancreatitis after an ERCP procedure. About 4050 adults aged 18-90 with an intact papilla will be randomly assigned to receive one of the d…

This study tests whether rinsing the bile duct opening with cold water, in addition to standard rectal indomethacin, can better prevent pancreatitis after ERCP—a common procedure to treat bile or pancreas issues. About 150 adults in India will be randomly assigned to get either t…

This study tests whether rinsing the bile duct opening with cold water at the end of an ERCP procedure, on top of standard medication, can reduce the risk of pancreatitis—the most common major complication after ERCP. About 950 adults with a natural papilla (the bile duct opening…

This study tests whether giving a short course of intravenous Ringer's lactate fluid around the time of an ERCP procedure can prevent pancreatitis, a common and serious side effect. Researchers will enroll 505 adults aged 18-75 who are having their first ERCP. Participants will r…

This study tests whether fecal microbiota transplantation (FMT) — transferring gut bacteria from healthy donors — can prevent infections in people with moderately severe or severe acute pancreatitis. About 150 adults will receive either FMT liquid or a placebo through a feeding t…

This study tests whether giving extra IV fluids along with a standard anti-inflammatory suppository can better prevent pancreatitis after a procedure to break up pancreatic stones. About 1250 adults with chronic pancreatitis will be randomly assigned to receive either the combina…

This study tests whether adding an oral medication (tacrolimus) before an ERCP procedure can prevent pancreatitis, a painful inflammation of the pancreas that sometimes occurs afterward. About 4,800 adults undergoing ERCP will be randomly assigned to receive either the standard r…

This study tests if spraying nitroglycerin directly into the bile duct during an ERCP procedure can prevent pancreatitis, a common and serious complication. About 440 adults who need ERCP to remove bile duct stones will take part. The goal is to see if this simple, local treatmen…

This study compares two ways to prevent pancreatitis after a procedure called ERCP: giving a rectal anti-inflammatory drug (NSAID) alone versus the drug plus placing a small tube (stent) in the pancreas. The trial enrolls about 1,278 high-risk patients aged 18-90 who have not had…

This study compares a low dose (50 mg) versus the standard dose (100 mg) of indomethacin given rectally before ERCP to prevent post-procedure pancreatitis. About 1,366 adults undergoing ERCP will be randomly assigned to one of the two doses in a double-blind fashion. The goal is …

This early-stage study tests if a single infusion of donor stem cells can reduce long-term pain from chronic pancreatitis. Researchers will enroll 48 adults with persistent pain and track changes in pain scores, opioid use, and quality of life over 6 months. The goal is to see if…

This early-stage trial tests whether stem cells taken from a patient's own bone marrow can reduce pain caused by chronic pancreatitis and possibly improve pancreas function. Forty adults with long-term painful pancreatitis will receive either the stem cells or a placebo. The stud…

This study is testing whether people with recurrent acute or chronic pancreatitis can safely drink a soy tomato juice beverage every day. Researchers will check for side effects, measure inflammation in the blood, and ask participants how they feel. The goal is to see if the drin…

This pilot study tests whether simvastatin, a common cholesterol medication, can improve quality of life in adults with recurrent acute or chronic pancreatitis. Researchers will enroll 90 participants to check if the drug is feasible and acceptable. The goal is to see if it helps…

This study tracks how well a nerve block procedure called celiac plexus neurolysis (CPN) helps manage pain in people with chronic pancreatitis. Researchers will follow 35 patients for 24 weeks, recording their pain scores and pain medication use. The goal is to see if the procedu…

This study tests an internet-delivered pain self-management program for adults with chronic pancreatitis who suffer from severe abdominal pain. The program uses psychological techniques to help reduce pain's impact on daily life and improve quality of life. Researchers aim to enr…

This early-phase trial tests whether paricalcitol, a vitamin D analog, can improve quality of life in adults with chronic pancreatitis. Researchers will enroll 24 participants to take either the drug or a placebo for 12 months. The main goal is to see if the study is feasible and…

This study tests whether increasing the dose of varenicline or adding bupropion helps people with recurrent acute or chronic pancreatitis quit smoking. All 45 participants start with standard varenicline; those still smoking after 6 weeks are randomly assigned to a higher dose, a…

This study tests a mobile app that gives personalized exercise coaching and feedback on blood sugar, sleep, and mood to help middle-aged adults with type 1 diabetes exercise more. Participants get a free Garmin smartwatch and program membership. The goal is to see if the app help…

This pilot study tests Scrambler Therapy, a non-invasive device that sends electrical signals through the skin to retrain the brain's pain response. Forty adults with chronic pancreatitis and persistent abdominal pain will receive 5-10 daily sessions. Researchers will measure pai…

This study at the National Institutes of Health is looking at 1,000 adults with known or suspected hormone gland (endocrine) disorders. The goal is to better understand these conditions and help train doctors. Participants may receive tests, treatments, or surgery as part of thei…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study reviews medical records from 3,000 patients who had emergency surgery at a Swedish hospital between 2009 and 2019. Researchers want to understand what factors increase risks and how patients fare in the long run, including complications, repeat surgeries, and survival.…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study reviews medical records of 500 adults treated for benign or malignant pancreatic diseases since 2005. The goal is to understand how well different treatments worked over time. No new treatments are given—just careful analysis of past cases.

This study enrolls adults with known or suspected endocrine (hormone gland) disorders, such as diabetes or thyroid disease, to help researchers learn more about these conditions. Participants will undergo medical exams, blood and imaging tests, and possibly genetic testing. The m…

This study is testing a new ultrasound method that uses tiny, safe bubbles to measure blood flow in the pancreas. The goal is to see if changes in blood flow can help detect type 1 diabetes early, before symptoms appear. Researchers will compare 50 healthy adults and people recen…

This study aims to collect and analyze pancreatic fluid from 24 healthy adults after giving them a synthetic hormone called secretin. The secretin is injected during an endoscopic ultrasound to stimulate the pancreas to release fluid, which is then collected from the duodenum. Re…

This study is for people at high risk of pancreatic cancer, such as those with a strong family history or certain genetic conditions. Researchers will use MRI and endoscopic ultrasound to screen participants regularly and see which method works best. The goal is to detect cancer …

This registry will follow 510 adults undergoing therapeutic endoscopic ultrasound (EUS) for conditions like stomach or bile duct blockages, pancreatic fluid collections, or gallbladder inflammation. The goal is to see how well these procedures work over the long term and what fac…

This study explores whether monitoring bowel sounds can help predict which patients with acute pancreatitis will develop a severe form of the disease. Researchers will enroll 352 adults across three hospitals and track their bowel sounds for at least 48 hours. The goal is to see …

The PREDICT study is creating a registry and biospecimen bank for people with pancreatic disease or at high risk for pancreatic cancer. Researchers will collect blood, tissue, urine, and other samples from 1,000 participants to study the causes and biology of the disease. This is…

This study is a registry that gathers information from up to 500 people in Russia who have extremely high triglyceride levels (a type of fat in the blood). The goal is to learn more about their health, genetics, and current treatments. No new drugs or procedures are tested—just o…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study collects blood, tissue, and health information from 20,000 people with pancreas diseases like pancreatic cancer, pancreatitis, or cysts. The goal is to create a large database and sample bank that researchers can use to better understand these conditions and develop be…

This study gathers blood, saliva, urine, and stool from up to 1,600 children with recurrent or chronic pancreatitis. Researchers look for genetic markers that might increase the risk of pancreatic cancer later in life. No treatment is given—the goal is simply to learn more about …

This study will review the medical records of 10 patients who developed acute pancreatitis within two weeks after a procedure to remove blood clots (percutaneous mechanical thrombectomy). The goal is to find out how often this complication happens, what patient or procedure facto…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This observational study will monitor 1,000 patients in Slovakia and Czechia who undergo ERCP, a procedure to treat bile duct problems. The main goal is to track how often pancreatitis occurs after the procedure and whether hospitals are following recommended prevention steps. Th…

This study follows 800 people who carry a mutation in the PRSS1 gene, which causes hereditary pancreatitis. Researchers will collect health data and questionnaires to track how often pancreatic cancer develops and how the disease progresses over time. The goal is to better unders…

This study looks at whether a continuous glucose monitor (CGM) can help predict who will develop diabetes after an episode of acute pancreatitis. Researchers will follow 800 people for up to 36 months, using the CGM device to track blood sugar levels. The goal is to see if CGM ca…

This study creates a registry of people with pancreatic diseases or a high risk for pancreatic cancer, such as those with a family history or certain genetic mutations. Researchers will collect medical information and blood samples to study how these conditions develop over time.…

This study compares two imaging techniques—laparoscopic ultrasound and a special dye called indocyanine green—to help surgeons see important bile duct structures during difficult gallbladder removal surgery. About 62 adults with conditions like acute cholecystitis, prior abdomina…

This study looks at whether feeding through a tube into the small intestine is better than eating by mouth after a procedure to drain a pancreatic cyst caused by severe pancreatitis. About 50 adults with this condition will be randomly assigned to one of the two feeding methods. …

This study is following 1,250 people at higher risk for pancreas cancer, including those with new diabetes, pancreatic cysts, or a family history. Researchers will collect blood samples and health data twice a year for several years. The goal is to find early markers in the blood…

This study follows 150 patients who have had part of their pancreas removed. Researchers will measure blood levels of amylase and lipase before, during, and after surgery to see if high levels can predict serious complications like pancreatitis. The goal is to improve how doctors…

This study looks at 500 adults with acute pancreatitis to find out how often blood clots form in the veins around the pancreas (splanchnic veins). Researchers will also check if these clots are linked to more severe pancreatitis. Participants will have imaging scans to detect clo…

This study tracks 1,000 patients undergoing major liver, pancreas, or bile duct surgery to see if the time it takes for their albumin levels to return to normal can predict complications and length of hospital stay. Albumin is a protein that drops after surgery due to inflammatio…

This study looks at whether a special pain test called Pancreatic Quantitative Sensory Testing (P-QST) can predict how well people with chronic pancreatitis will respond to treatments like endoscopy or surgery. About 150 adults with chronic pancreatitis and ongoing pain will take…

This study uses a technique called Quantitative Sensory Testing (QST) to understand different pain patterns in people with chronic pancreatitis. By mapping how the nervous system processes pain, researchers hope to predict which patients will benefit from specific treatments like…

This study is looking for ways to predict which people with chronic pancreatitis will get pain relief from a procedure called endoscopic therapy. Researchers will use brain scans, nerve tests, and questionnaires before the procedure, then track pain levels for up to 18 months. Th…

This study looks at blood markers and how well transplanted insulin-making cells (islets) work in people with chronic pancreatitis who have their pancreas removed and get their own islets back. Researchers will follow 100 adults for at least two years to understand graft function…

This study is for people with pancreatic cysts or other pancreas issues. Researchers will collect blood, tissue, and scan data from over 1,100 participants to create a large database. The goal is to develop noninvasive tools that predict which cysts may become cancerous, helping …

This study aims to create a simple, minimally invasive test to find pancreatic cancer at an early stage and track how well treatment is working. Researchers will study 700 people with pancreatic cancer, pancreatitis, or pancreatic cysts. The goal is to identify biological markers…

This study follows 800 people who recently had acute pancreatitis to see who develops diabetes and why. Participants are observed for 36 months with tests and surveys. No new treatments are tested; the goal is to learn how and why diabetes occurs after pancreatitis.

This study aims to collect medical history, family history, and blood or urine samples from 10,000 people with or at risk for pancreatic cancer. Researchers will use this information to look for genetic and environmental factors linked to the disease. Participants may also be ask…

This study is a registry that will follow 1,000 people who receive standard endoscopic treatment for fluid collections caused by pancreatitis. The goal is to see how well the procedure works and what outcomes patients experience. No new treatment is being tested—this is about gat…

This study is following over 2,300 people across the US to better understand chronic pancreatitis, a painful long-term condition of the pancreas. Researchers will track participants' symptoms and disease changes over time to identify what causes the disease and how it progresses.…

This study follows 200 adults with severe pancreatitis and sepsis who undergo open necrosectomy, a surgery to remove dead tissue. Researchers will measure how well the heart, lungs, and kidneys work over time using a standard scoring system. The goal is to understand how organ fu…

This study tracks 300 adults in Tehran who are getting a pancreas biopsy (EUS-guided FNB) to see how often pancreatitis occurs afterward. Researchers will measure enzyme levels 24 hours later and check for pain. The goal is to find out which factors—like age, gender, or biopsy lo…

This study follows 250 patients who are having surgery to remove part of their pancreas due to cancer, pancreatitis, or cysts. Researchers will track changes in quality of life, symptoms, and emotional well-being for up to two years after surgery. The goal is to understand how th…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …