Cold water trick may stop pancreatitis after common procedure

NCT ID NCT07330284

Recruiting now Prevention Sponsor: University of Kansas Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether rinsing the bile duct opening with cold water at the end of an ERCP procedure, on top of standard medication, can reduce the risk of pancreatitis—the most common major complication after ERCP. About 950 adults with a natural papilla (the bile duct opening) will be randomly assigned to receive either cold or room-temperature water irrigation. The main goal is to see if cold water lowers the rate of post-ERCP pancreatitis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cold water irrigation
What this could lead to: If it works, this simple, low-cost addition could become a standard step during ERCP to prevent pancreatitis, the most common serious complication.
What could go wrong: This is an early-stage trial with no phase designation, so results are uncertain. The benefit may be small or not apply to all patients, and cold water could cause discomfort or other minor side effects.

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Conditions

The condition(s) this trial relates to.

pancreatitis acute pancreatitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ERCP SURGERY PANCREATITIS

Contacts and locations

Locations

University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States

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