University Of Kansas Medical Center

This early-stage trial tests a new treatment called DuoCAR20.19.22-D95 for adults with B-cell lymphoma or leukemia that has returned or not responded to standard therapy. The treatment uses a patient's own immune cells, which are modified in the lab to better recognize and attack…

This study looks at what happens to your body when you take anti-obesity medications like semaglutide or tirzepatide, and whether adding aerobic or resistance exercise helps preserve muscle and bone while losing fat. About 40 adults will be assigned to either standard care (medic…

This early-phase trial tests a combination of two drugs, tagraxofusp and pacritinib, in about 20 adults with myelofibrosis (a bone marrow disorder) who have already tried standard JAK inhibitors or cannot use them. The main goals are to see if the combo can shrink an enlarged spl…

This phase 2 trial is testing two standard chemotherapy combinations given before surgery for people with HER2-positive early breast cancer. One group gets docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP); the other gets the same without carboplatin (THP). The main goal…

This study looks at whether providing free bags of groceries to patients undergoing stem cell transplants or CAR-T cell therapy can help improve their nutrition and treatment results. Many patients face high medical costs that make it hard to afford enough food, which can hurt th…

This phase 2 trial is testing whether metformin, a common diabetes drug, can improve airway function in 30 adults with cystic fibrosis-related diabetes who are already on CFTR modulator therapy. Researchers will measure changes in ion channel activity in nasal cells. The study ai…

This study tests whether a family-focused healthy lifestyle program (iAmHealthy) plus clinic-level changes can help manage obesity in children aged 6–11 living in rural areas. Over 1,000 families will take part in group education sessions and individual health coaching, or receiv…

This early-phase trial tests whether giving patients extra gamma delta T-cells—a type of immune cell that can kill cancer—after a half-matched bone marrow transplant can improve outcomes. The study includes up to 38 adults with leukemia or myelodysplastic syndromes. The goal is t…

This study tests whether a supplement called HMB can help female athletes regain muscle mass and strength after ACL knee surgery. About 30 women will receive either HMB or a placebo for several months after their operation. Researchers will measure muscle size and strength to see…

This study tests whether taking the quit-smoking drug bupropion for 6 months works better than the usual 7-week course for African American adults who smoke daily. Researchers will enroll 500 participants and check if more people stay smoke-free at 6 months with the longer treatm…

This study is testing a precise, high-dose radiation treatment called SABR as an alternative to surgery for women aged 65 and older with early-stage breast cancer. The goal is to control the cancer while avoiding surgery and maintaining quality of life. Participants will receive …

This study tests whether adding pirfenidone to the immunotherapy drug atezolizumab can help shrink tumors and prevent treatment resistance in people with advanced or returning non-small cell lung cancer. About 25 adults with stage IV or recurrent NSCLC who have already tried at l…

This study tests whether a 4th-generation nicotine salt e-cigarette, combined with the drug varenicline, can help people who both smoke and vape reduce their exposure to harmful chemicals and quit regular cigarettes. Researchers will enroll 500 adults who smoke at least 5 cigaret…

This early-phase trial tests a special radiation technique called vGRID SBRT for people with liver cancer that cannot be surgically removed. The main goal is to find the highest safe dose and check for side effects. Up to 18 adults with advanced or metastatic liver cancer will re…

This study helps early-stage endometrial cancer survivors with obesity start a weight management program and possibly take weight loss medications. Researchers want to see if referring patients to a weight loss clinic helps them begin treatment. The goal is to improve long-term h…

This study compares two medications applied to the wound bed before placing a skin graft in people with burns. The goal is to see if a low-cost drug called tranexamic acid works as well as the standard thrombin spray to prevent blood clots under the graft. About 62 adults with sm…

This study tests whether adding hands-on cooking classes to a standard weight loss program helps young adults (18-35) with mild-to-moderate intellectual disabilities lose more weight and keep it off. Over 24 months, 114 participants will either follow a healthy eating plan with c…

This study tests whether rinsing the bile duct opening with cold water at the end of an ERCP procedure, on top of standard medication, can reduce the risk of pancreatitis—the most common major complication after ERCP. About 950 adults with a natural papilla (the bile duct opening…

This study tests whether a dietary supplement called galacto-oligosaccharide (GOS) can prevent acute graft-versus-host disease (GVHD) in people receiving a stem cell transplant. GVHD is a serious complication where donor cells attack the patient's body. The supplement aims to cha…

This study looks at whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. About 81 participants without dementia will either follow a reduced-calorie diet with monthly coaching or attend general health education sessions. Over 12 months…

This study looks at two different ways to help adults in rural communities prevent type 2 diabetes. Participants will either join group video sessions or follow a self-directed program. The goal is to see which method works better for weight loss and blood sugar control.

This study tests whether combining text message support with financial incentives helps low-income pregnant women quit smoking more than text messages alone. Thirty pregnant women who smoke will be split into two groups to see which approach is more acceptable and effective. The …

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce fatigue in people with multiple sclerosis. About 70 adults with MS and insomnia will receive CBT-I or an active control. The goal is to see if this talk therapy approach can ea…

This study compares two types of nerve blocks—ESPBs and TAPs—for controlling pain after DIEP flap breast reconstruction surgery. About 102 women with breast cancer will receive one of the two blocks before surgery. The goal is to see if the newer ESPB method provides equivalent p…

This study compares two steroid injections for knee osteoarthritis in people with type 2 diabetes. It aims to see which one controls pain better while causing fewer blood sugar spikes. About 120 adults with diabetes and knee arthritis will receive either a long-acting or short-ac…

This study compares two types of lasers (holmium:YAG and thulium fiber) used during a minimally invasive surgery to break up large kidney stones. About 150 adults with stones larger than 15 mm will be randomly assigned to one laser or the other. The goal is to see which laser wor…

This study compares a new, thinner flexible scope (HugeMed 6.3 French) to standard scopes for removing kidney stones up to 2.5 cm. Researchers want to see if the new scope saves money while still clearing stones just as well. About 75 adults with kidney or ureter stones will take…

This study looks at whether people who have surgery for a detached retina need to keep their head in a specific position for seven days, or if just one day is enough. About 20 adults with a certain type of retinal detachment will be asked to stay prone for only one day after thei…

This study tests whether guided imagery—specifically, vividly imagining a future where you are physically active—can help mid-life adults stick to an exercise program. 160 participants will complete an in-person exercise program and be randomly assigned to different imagery exerc…

This study looks at how much pelvic pain is reduced in women with Pelvic Congestion Syndrome after a procedure called gonadal vein embolization. About 30 women will take part, and researchers will use a simple survey to measure pain before and after treatment. They also want to f…

This study compares two types of anesthesia given during surgery to remove a blood clot from the brain after a stroke. One is inhaled (sevoflurane) and the other is given through a vein (propofol). Researchers want to see which method leads to better recovery and independence 90 …

This study looks at whether adding yoga to a standard weight loss program helps adults with overweight or obesity lose more weight than just aerobic exercise alone. About 290 participants will follow a 12-month program with diet changes and either aerobic exercise plus yoga or ae…

This study tests a text message program called CuidaTEXT for Latino caregivers of relatives with Alzheimer's. About 288 caregivers will receive educational and support texts or no texts. The goal is to see if the texts reduce depressive symptoms and stress over 6 months.

This study tests a special needle (multi-tined expandable electrode) used in a standard procedure called radiofrequency ablation to treat chronic low back pain. About 50 adults with long-term pain will either get this new needle treatment or continue with usual medical care. The …

This study tests two ways of delivering cognitive behavioral therapy for insomnia (CBT-I) to people with multiple sclerosis: one-on-one telehealth sessions or a self-guided web program. Researchers will compare these to usual care to see which improves sleep, reduces fatigue, and…

This study looks at whether giving a lower dose of immunotherapy (pembrolizumab or nivolumab) causes fewer serious side effects than the standard higher dose. About 192 adults with solid tumors will be randomly assigned to receive either the higher or lower dose. The main goal is…

This study looks at how mucus plugs in the lungs affect breathing in people with severe asthma. Researchers will use special MRI scans to see air flow in blocked areas. Only 5 adults with severe asthma will take part, and the goal is to better understand lung function, not to tes…

This study tracks how orthopedic surgery changes your resting metabolic rate (the calories you burn at rest) and how long it takes to return to normal. Researchers will measure 100 patients before and after surgery using simple tests like urine samples and a metabolic cart. The g…

This study looks at whether pregnant women who eat 10-14 eggs per week have babies with better brain development compared to those who just follow a healthy prenatal diet. Researchers will measure fetal heart rate and later do brain scans on the infants. The goal is to see if boo…

This study follows about 200 gender minority adults to see if starting gender-affirming hormone therapy changes chronic pain over time. Participants fill out surveys and some also get brain scans and sensory tests. The goal is to understand how hormones, stress, and social factor…

This study follows 450 people with FSHD for at least 3 years to measure how the disease affects walking, arm use, breathing, and other daily activities. The goal is to improve patient care and help researchers design better clinical trials by understanding what changes in movemen…

This study is looking at how the shape and alignment of the kneecap joint relate to knee pain. Researchers will take 3D CT scans of the knee while people stand (weight-bearing) to see the joint in a natural position. They hope to find links between specific bone measurements and …

This study is testing a device called RetroPerc, which helps doctors reach kidney stones during surgery. About 150 adults with kidney stones will take part. The goal is to see how often the device successfully gets to the stone and how long it takes.

This study is testing a new way to measure balance in adults with spinal deformity (like scoliosis). Researchers will use a 'functional reach test' where participants reach forward and sideways while wearing motion sensors. The goal is to give surgeons better information about ba…

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this information to better understand imaging biomarkers and develop new analysis methods for CT and MRI scans. Participants must alr…

This study is testing whether a program delivered remotely (by video or phone) that combines exercise and dementia caregiving support is practical and helpful for older adults with Down syndrome and their caregivers. About 40 participants will take part. The goal is to see if the…

This study looks at tiny particles called exosomes in the blood of 30 adults with rectal cancer who are getting chemotherapy and radiation before surgery. The goal is to see if changes in these particles can predict how well the tumor responds to treatment. This is an observation…

This study is testing a new ureteroscope that shows surgeons the pressure inside the kidney in real time during stone removal. Researchers want to see if having this information changes how surgeons operate and leads to better outcomes. The study will enroll 80 adults with large …

This study uses a special type of MRI called hyperpolarized xenon MRI to take detailed pictures of the lungs in 260 healthy young adults. The goal is to find early signs of lung damage that could lead to chronic lung disease later in life. Participants are already part of a large…

This observational study is collecting blood and urine samples from 250 people with early-stage polycystic kidney disease (PKD), their unaffected family members, and healthy volunteers. The goal is to create a biobank that researchers can use to find biological markers of disease…

This study explores whether placing community health workers in rural schools can help students with poor attendance by addressing underlying social needs like housing, food, or healthcare. Researchers will work with about 126 students in grades 6-12 and their families to see if …

This study tests whether teaching parents to talk more with their babies during regular well-child visits can improve language development. Researchers will enroll 400 parent-child pairs and compare those who receive the 'Talk With Me Baby' coaching to those who get standard care…

This study tracks how bladder cancer treatment affects patients' energy needs and muscle function. Researchers will measure resting energy use and collect blood samples from 30 patients before and after chemotherapy and surgery. The goal is to learn more about these changes so fu…

This study tests a method called NPT-PLA to help 20 primary care clinics better use a decision-making tool that encourages colorectal cancer screening. About 2,200 patients and staff will take part. The goal is to see if this approach leads to more screening orders and completion…

This study is creating a large registry and biorepository of information and samples from 1,000 people with bladder cancer. Researchers will collect blood, urine, and tissue samples over two years to study how they relate to tumor development, recurrence, and survival. The goal i…

This study is testing different ways to measure muscle strength and movement in children with a rare muscle disease called FSHD. The goal is to find the best tests to use in future studies of new treatments. About 80 children aged 5 to 17 with confirmed FSHD will take part. The r…

This study looks at how estrogen levels influence body composition and muscle function in midlife women (ages 35-60) who are starting a GLP-1RA medication for weight loss. Researchers will measure changes in weight, muscle mass, bone density, and strength over time. The goal is t…

This study tests a 12-week mobile app program for parents of 3-4 year olds who currently meet few movement guidelines. Children wear activity trackers, and parents get weekly tips and goals through the app. The goal is to see if the app helps kids get more physical activity, bett…

This study follows 50 adults in a community weight loss program to see how daily stress levels relate to weight loss, physical activity, and sleep. Participants will answer quick surveys on their phones and wear a wrist device to track activity and sleep. The goal is to understan…

This study is testing a 6-session family program called NOURISH-ALL for children ages 2-12 with acute lymphoblastic leukemia (ALL) and their caregivers. The program focuses on healthy eating, physical activity, and reducing family stress during early treatment phases. The main go…

This registry tracks up to 1,500 people with triple negative breast cancer or inherited genetic mutations (like BRCA). Researchers will study how often these mutations occur, how patients respond to chemotherapy, and long-term survival. The goal is to better understand the diseas…

This study is creating a registry and biobank for people with interstitial lung diseases (ILD), including sarcoidosis, idiopathic pulmonary fibrosis, and hypersensitivity pneumonitis. Researchers will collect medical data and biological samples from up to 1,000 participants to su…