University Of Kansas Medical Center

This early-phase trial tests two drugs, tagraxofusp and pacritinib, together in about 20 adults with myelofibrosis (a bone marrow disorder) who have already tried standard JAK inhibitors or cannot take them. The main goals are to see if the combination can shrink an enlarged sple…

This study is for people with certain blood cancers (like leukemia) who are getting a half-matched bone marrow transplant. Researchers are adding a dose of specially grown immune cells (gamma delta T-cells) after the transplant to see if it can kill any leftover cancer cells whil…

This study tests whether a new clinical guideline can help rural children ages 6-11 who have overweight or obesity. About 1,024 children and their families will either receive a family-based healthy lifestyle program (iAmHealthy) or a newsletter, while clinics may also get extra …

This study tests whether adding pirfenidone to the immunotherapy drug atezolizumab can improve tumor shrinkage and reduce treatment resistance in people with stage 4 or recurrent non-small cell lung cancer. About 25 adults who have already tried at least one prior treatment will …

This study compares two medications applied to the wound bed before placing a skin graft in people with burns. The goal is to see if a low-cost drug called tranexamic acid works as well as the standard thrombin spray to prevent blood clots under the graft. About 62 adults with sm…

This study tests a high-precision radiation treatment called SABR for women aged 65 and older with a common type of early breast cancer. Participants receive five focused radiation sessions instead of surgery. The goal is to control the cancer while keeping side effects low and p…

This study looks at whether new, fourth-generation e-cigarettes can help adults who both smoke and vape reduce their exposure to harmful chemicals and quit smoking regular cigarettes. About 500 participants will be followed for several weeks, and some will also receive a medicati…

This study looks at how adding exercise to anti-obesity medications affects body composition, like muscle and fat. About 40 adults taking weight-loss drugs will either do no extra exercise, aerobic training, or resistance training for 6 months. Researchers will measure changes in…

This study tests whether metformin, a standard diabetes medicine, can improve airway cell function in adults with cystic fibrosis-related diabetes (CFRD). Participants must already be taking a CFTR modulator drug. The trial involves 30 people and measures changes in ion channel a…

This study tests a new radiation therapy called vGRID SBRT for people with liver cancer that cannot be removed by surgery. The goal is to find the highest safe dose and see how well it controls tumors. About 18 adults with advanced liver cancer will take part. The approach aims t…

This study tests whether a supplement called HMB can help female athletes regain muscle size and strength after ACL knee surgery. About 30 women will take either HMB or a placebo daily during their recovery. Researchers will measure muscle changes and strength over several months…

This study looks at how doctors can help endometrial cancer survivors who are overweight start a weight management program and possibly take weight loss medication. About 50 people who have finished early-stage endometrial cancer treatment will be referred to a weight loss clinic…

This study tests whether taking the smoking cessation drug bupropion for 6 months helps African American daily smokers quit more successfully than the standard 7-week treatment. About 500 participants will be followed for 6 months to see who stays smoke-free. The goal is to find …

This study tests two different drug combinations given before surgery for HER2-positive breast cancer. About 100 adults with early-stage disease will receive either TCHP or THP to see which leads to a higher rate of complete tumor disappearance. The goal is to improve treatment a…

This study is testing whether adding hands-on cooking classes to a standard weight management program helps young adults with intellectual disabilities lose more weight and maintain that loss over two years. Researchers will compare a group receiving the standard program with a g…

This study tests two ways to deliver the National Diabetes Prevention Program to adults in rural areas who are at risk for diabetes. One group joins video sessions, while the other follows a self-directed plan. Researchers will track weight and blood sugar changes over 12 months …

This study tests whether rinsing the bile duct opening with cold water at the end of an ERCP procedure, in addition to standard medication, can lower the chance of developing pancreatitis—the most common serious complication after ERCP. About 950 adults with a natural bile duct o…

This study tests whether a dietary supplement called galacto-oligosaccharide (GOS) can prevent acute graft-versus-host disease (GVHD) in people receiving a stem cell transplant. About 128 adults aged 18-80 will take GOS or a placebo to see if it helps keep gut bacteria healthy an…

This study is testing whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. Researchers will compare a weight loss program to general health education in 81 adults with Down syndrome who are overweight but do not have dementia. The stud…

This study compares two FDA-approved lasers (Holmium:YAG with MOSES and thulium fiber) for breaking large kidney stones during a minimally invasive surgery called mini-PCNL. About 150 adults with stones larger than 15mm will be randomly assigned to one laser, both using a suction…

This study looks at whether people who have surgery for a detached retina need to keep their head face-down for one day instead of the usual seven. About 20 adults with a specific type of detachment will be asked to stay face-down for just 24 hours after surgery. The goal is to s…

This study tests a smoking cessation program for low-income pregnant women. It combines text message support with financial rewards to see if it helps them quit. The study will compare this approach to text messages alone and measure how well it works and if participants find it …

This study tests a text message program called CuidaTEXT for Latino caregivers of relatives with Alzheimer's. About 288 caregivers will receive educational and support texts or no texts. The goal is to see if the texts reduce depressive symptoms and stress over 6 months.

This small study is testing whether taking whey protein can increase antioxidant levels in the brain and improve physical function, thinking skills, and body composition in older adults who are pre-frail. Twenty participants aged 65 to 85 will take whey protein and undergo MRI sc…

This study looks at how much pelvic pain is reduced after a procedure called gonadal vein embolization in women with pelvic congestion syndrome. Researchers will use a simple survey to measure pain levels before and after treatment. They also want to find out which patients are m…

This study compares a new type of needle used in a standard pain-relief procedure (radiofrequency ablation) against usual medical care for people with chronic low back pain. About 50 adults with pain lasting at least 6 months will be enrolled. The goal is to see if the new needle…

This study tests two ways to deliver cognitive behavioral therapy for insomnia (CBT-I) to people with multiple sclerosis: one-on-one telehealth sessions or a self-guided web program. Researchers want to see which approach improves sleep, reduces fatigue, and may protect the brain…

This study looks at whether a lower dose of common immunotherapy drugs (pembrolizumab or nivolumab) causes fewer serious side effects than a higher dose. About 192 adults with solid tumors will be randomly assigned to receive either a higher or lower dose. The goal is to find the…

This study creates a registry of lung images and biological samples from 100 people with lung disease. Researchers will use this information to better understand new imaging techniques and develop tools for future diagnosis. Participants must already be enrolled in a lung MRI or …

This study looks at how bladder cancer treatment affects patients' energy needs and muscle function. Researchers will measure resting energy use before and after chemotherapy and surgery in 30 adults. The goal is to learn how to better support patients during treatment, not to te…

This study tests whether a simple planning tool helps more people get screened for colorectal cancer. About 2,200 patients from 20 clinics will use the tool to decide on stool tests or colonoscopy. The goal is to see if clinics can successfully add this tool to routine care and i…

This study is looking at tiny particles called exosomes in the blood of people with rectal cancer. The goal is to see if these particles can help predict how well a patient responds to chemotherapy and radiation before surgery. Researchers will compare exosome levels before, duri…

This study tests a program called Talk With Me Baby, which teaches parents how to have more language-rich interactions with their infants during regular well-child doctor visits. Researchers will enroll 400 parent-child pairs and compare those in clinics using the program to thos…

This study looks at whether giving surgeons live information about pressure inside the kidney during a stone-removal procedure changes the way they work. About 80 adults with large kidney stones will take part. The main goal is to see if the pressure data improves the surgeon's n…

This study looks at how daily stress and related feelings impact weight loss, physical activity, and sleep in 50 adults with obesity who are already in a weight loss program. Participants will wear a device to track activity and sleep, and answer short surveys on their phones abo…

This study is a registry for people with triple negative breast cancer or those with inherited gene mutations like BRCA1/2. It aims to learn how often these mutations occur and how they affect treatment response and long-term survival. Up to 1,500 participants will be followed ov…

This study uses a special type of MRI, called hyperpolarized xenon MRI, to take detailed pictures of the lungs in 260 healthy young adults. The goal is to find early signs of lung problems that could lead to chronic lung disease later in life. Participants are already part of a l…

This study is creating a registry and biobank for people with interstitial lung disease (ILD), including sarcoidosis, pulmonary fibrosis, and hypersensitivity pneumonitis. Researchers will collect medical data and biological samples from up to 1,000 participants to better underst…

This study will follow about 200 gender minority adults, some starting gender-affirming hormone therapy and some not, to see how chronic pain changes over a year. Participants will fill out surveys, and some will also have pain sensitivity tests, brain MRIs, and interviews. The g…

This study looks at how the shape and movement of the kneecap relate to knee pain in people with patellofemoral pain (runner's knee) or knee osteoarthritis. Researchers will use special CT scans taken while standing to measure the knee's structure. The goal is to find links that …

This study aims to create a better way to measure balance in adults with spinal deformities like scoliosis. Researchers will use a simple reach test and motion sensors to see how far people can lean without losing balance. The study includes 30 patients scheduled for spine surger…

This study collects blood, urine, and health information from 250 people with early-stage polycystic kidney disease (PKD), their unaffected siblings, and healthy volunteers. The goal is to create a biobank that helps researchers find biological markers of early disease changes. T…

This study looks at whether eating 10-14 eggs per week during pregnancy can improve a baby's brain development. Eggs are rich in choline, a nutrient important for the fetal brain. About 100 pregnant women will be split into two groups: one that gets advice to eat more eggs, and a…

This study tests whether guided imagery—creating mental pictures of future rewards—can help mid-life adults stay motivated to exercise. 160 physically inactive adults will complete an exercise program and undergo MRI scans, questionnaires, and blood tests to see if this technique…

This study is testing whether a remotely delivered exercise and dementia care program is practical and helpful for older adults with Down syndrome (age 35+) and their caregivers. The goal is to see if people will join, stay in, and safely complete the 12-week program. It also loo…

This study looks at how well a device called RetroPerc helps doctors reach and remove kidney stones during a standard surgery. About 150 adults who are already scheduled for this surgery will take part. The goal is to see if the device makes the procedure more successful and fast…

This study tests whether a home-based mobile app can help parents of 3-4 year olds improve their child's daily physical activity, sleep, and screen time. About 80 children who currently meet few or no movement guidelines will wear activity trackers and have motor skills tested. P…

This study tests a 6-session family program for children ages 2-12 with acute lymphoblastic leukemia (ALL) and their caregivers. The goal is to see if families find the program helpful and easy to stick with. The program focuses on healthy eating, physical activity, and reducing …

This study is creating a registry—a bank of information and samples (blood, urine, tissue) from 1,000 people with bladder cancer. Researchers will use this data to learn more about how bladder cancer develops, comes back, and affects long-term survival. The goal is to support fut…

This study is for children aged 5 to 17 with a confirmed form of muscular dystrophy called FSHD. The main goal is to check if certain tests of movement and muscle strength are reliable and useful for future clinical trials. Researchers will also use MRI scans to measure muscle he…

This study looks at how mucus plugs in the lungs of people with severe asthma affect their ability to breathe. Researchers will use special MRI scans to see air flow in areas blocked by mucus. Five adults with severe asthma will be scanned before and after starting a new biologic…

This study compares two ways of giving anesthesia during emergency stroke surgery: one through a vein (propofol) and one inhaled (sevoflurane). Researchers want to see which method helps patients recover better 90 days after their stroke. The study will enroll 120 adults having s…

This study looks at whether providing bags of food to patients who have trouble affording groceries can improve their nutrition and health during stem cell transplant or CAR-T therapy. About 210 children and adults (ages 8-80) who screen positive for food insecurity will receive …

This study looks at how estrogen levels influence changes in body composition, muscle function, and bone health in women aged 35-60 who are starting a GLP-1RA medication for weight loss. Researchers will measure weight, lean and fat mass, bone density, and muscle strength. The go…