Weight loss may shield down syndrome adults from Alzheimer's

NCT ID NCT05985486

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. About 81 participants without dementia will either follow a reduced-calorie diet with monthly coaching or attend general health education sessions. Over 12 months, researchers will measure blood markers, thinking skills, and brain scans to see if weight loss makes a difference.

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Conditions

The condition(s) this trial relates to.

Down syndrome Obesity obesity disorder Alzheimer disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Kansas Medical Center

    RECRUITING

    Kansas City, Kansas, 66160, United States

    Contact