DOWN SYNDROME

This study tests whether adding nivolumab to blinatumomab helps children and young adults (ages 1 to 30) with B-cell acute lymphoblastic leukemia that has returned after initial treatment. Participants receive either blinatumomab alone or with nivolumab. The goal is to see if the…

This study tests a program called HomeGrown that helps families of young children with Down syndrome (ages 2-6) create healthier home environments. The goal is to improve eating habits and physical activity to prevent obesity. About 38 families will be randomly assigned to start …

This study compares personalized surgery guided by a special camera during sleep (DISE) to standard tonsillectomy for treating obstructive sleep apnea in 303 children with Down syndrome, ages 2 to 17. Sleep apnea is very common in these children and standard surgery often fails. …

This is the first study in humans to test the safety and tolerability of a new oral drug called Leucettinib-21. It will involve healthy volunteers and a small group of people with Down syndrome or Alzheimer's disease. The main goal is to see how the body handles the drug and to c…

This study tests if levetiracetam, a seizure medication, can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and poss…

This study is testing whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. Researchers will compare a weight loss program to general health education in 81 adults with Down syndrome who are overweight but do not have dementia. The stud…

This study aims to help young people with Down syndrome (age 12 and older) and their caregivers sleep better and feel better. Researchers will adapt a virtual mindfulness program for insomnia and test it in a small trial with 20 participants. The goal is to see if the therapy imp…

This study tests whether using a Powerball (a spinning hand exercise device) on a stable surface or an unstable surface (BOSU ball) can improve arm endurance and coordination in children with Down syndrome. Twenty-eight children ages 6-10 will do 30-minute sessions three times a …

This study looks at two types of exercise—Cuevas Medak and Rebound—to see which one better improves physical fitness in children with Down syndrome. Twenty-two kids aged 3 to 8 will do their assigned exercises three times a week for 12 weeks. Researchers will measure flexibility,…

This study will test whether the OTAGO exercise program can improve balance, endurance, and motor coordination in children with Down syndrome. Thirty children aged 8 to 14 with mild to moderate intellectual disability will participate. They will follow the exercise program, and r…

This study looks at whether jumping rope can help improve foot posture in children with Down syndrome who have flat feet. Researchers will split 32 children, ages 4 to 15, into two groups: one will jump rope and play, the other will just play. Foot changes will be measured before…

This study tests a personalized approach to treat obstructive sleep apnea (OSA) in people with Down syndrome. Researchers will compare giving everyone the same drug combination (atomoxetine and oxybutynin) versus assigning either that drug or oxygen therapy based on each person's…

This study tests a special nasal tube (ssNPA) that stays in place without tape or ties, designed to help children with weak throat muscles breathe easier during sleep. About 40 children with obstructive sleep apnea and conditions like Down syndrome will try the device overnight. …

This study is testing whether Vojta therapy, a specific physical therapy approach, can improve walking and overall movement abilities in children with Down syndrome. It involves 28 children aged 2-10 who can stand and walk independently. Children will be randomly assigned to rece…

This study looks at the medical records of 1,000 children with conditions like autism, epilepsy, and Down syndrome. The goal is to find common biological patterns that may help explain why these disorders develop. Researchers hope this will lead to better diagnosis and treatment …

This study looks at 40 children with Down Syndrome who have pneumonia. Researchers measure immune markers in the blood and breathing rate and oxygen levels to see if they are connected. No treatment is given; the goal is to understand the relationship better.

This study is for people with Down syndrome who have had acute leukemia and are now at least 6 years old. Researchers want to learn about long-term health problems that may appear after cancer treatment. By understanding these risks, doctors hope to create better follow-up care g…

This study explores whether a non-invasive method using light, sound, and vibration can safely change brain activity in adults with Down Syndrome. Researchers will monitor brain waves and check for side effects during a single session. The goal is to see if this approach is feasi…

This study follows 700 people with Down syndrome (and some healthy relatives) for up to 15 years to understand how their immune system changes over time. Researchers will look at infections, autoimmune problems, and blood cancers, and compare those who had part of their thymus re…

This study aims to enroll up to 550 adults with Down syndrome, ages 25-55, into a 'trial-ready' group. Researchers will track memory, thinking, genetics, and brain changes over time to better understand Alzheimer's disease in this population. The goal is to prepare a group of vol…

This study looks at how the autonomic nervous system (which controls heart rate and blood pressure) works in people with Down syndrome. Researchers will measure heart rate, blood pressure, and stress hormones during activities like cold water, fear simulations, exercise, and caff…

This study tests a program called PACE that helps adults with intellectual disability become more physically active. About 120 adults, along with their caregivers and coaches, will take part. The program focuses on increasing daily steps and moderate-to-vigorous activity, and the…

This study is looking at whether simple, non-invasive eye scans can help detect and track brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will use special cameras to take detailed pictures of the retina in 2,000 adults—both those with and without…

This study creates a large collection of blood, saliva, urine, and other samples from 2,500 people with and without Down syndrome. Researchers will use these de-identified samples and medical records to better understand the health conditions that often accompany Down syndrome. T…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already taking these drugs as part of their regular care, or have had a recent CO…