DOWN SYNDROME

This study tests a 6-month family-based program called HomeGrown, designed to help parents of young children (ages 2-6) with Down syndrome create healthier home environments. Families get online tools, resources, and monthly coaching calls to improve nutrition and physical activi…

This phase 2 trial is testing whether adding nivolumab to blinatumomab helps children and young adults (ages 1 to 30) with relapsed B-cell acute lymphoblastic leukemia (B-ALL), including those with Down syndrome. Blinatumomab helps the immune system find and kill cancer cells, wh…

This study tests whether tofacitinib, a drug used for arthritis, can improve thinking skills and immune function in people with Down syndrome aged 6 to 22. Half of the 92 participants will receive the drug for 6 months, and the other half a placebo. Researchers will measure chang…

This study tests whether matching sleep apnea treatment to the specific cause in each person with Down syndrome works better than a one-size-fits-all approach. 200 children and adults will receive either a combination of two drugs (ato-oxy) or oxygen therapy based on their indivi…

This study tests a 16-week inclusive exercise program called PACE for adults with intellectual disability. Participants will attend fitness classes, meet with coaches, and use a web dashboard to set goals. The trial includes 376 people and will measure daily steps and moderate-to…

This study compares personalized surgery guided by a special camera during sleep (DISE) to standard tonsil and adenoid removal for treating obstructive sleep apnea in 303 children with Down syndrome, ages 2 to 17. Sleep apnea is very common in these children and standard surgery …

This study looks at whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. About 81 participants without dementia will either follow a reduced-calorie diet with monthly coaching or attend general health education sessions. Over 12 months…

This study tests if the drug levetiracetam can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and possibly slow brai…

This study tests whether a non-invasive brain stimulation technique called tDCS can help adults with Down syndrome who have depression with catatonia (a state of being unresponsive or stuck). 62 participants will receive either real or fake (sham) tDCS for 15 sessions over 5 days…

This study tests whether two months of drumming lessons can improve self-control and timing skills in children with Down syndrome. Thirty children aged 7 to 15 will take lessons from a professional drummer and complete computer tasks and brain recordings. The goal is to see if rh…

This study tests whether playing a bean bag tossing game on a wedge or a balance board can improve balance and walking in children with Down syndrome. Thirty-six children aged 7-12 will be split into two groups and play the game for 30 minutes, three times a week, for four weeks.…

This study looks at whether the OTAGO exercise program can improve balance, endurance, and motor coordination in children with Down syndrome. Researchers will work with 30 children aged 8 to 14 who have mild to moderate intellectual disability. Over ten months, the children will …

This study tests a mindfulness-based therapy designed to improve sleep in people with Down syndrome (age 12+). The program is adapted with visual aids, shorter meditations, and caregiver support. Researchers will compare it to a brief behavioral therapy in 20 participants, measur…

This study tests a special nasal airway device (ssNPA) in 40 children with weak throat muscles and obstructive sleep apnea, including those with Down syndrome. The device is designed to keep the airway open during sleep without needing surgery. Researchers will measure how well i…

This study looks at whether jumping rope can improve foot posture in children with Down syndrome. Researchers will include 32 children aged 4 to 15 who have flat feet. One group will jump rope and play, while the other group only plays. Foot changes will be measured before and af…

This study compares two types of exercise—cognitive-motor training (combining thinking tasks with movement) and Pilates—to see which better improves balance in children with Down syndrome. Thirty-two children aged 8 to 13 will be randomly assigned to one of the two groups and tra…

This study looks at two types of exercise—Cuevas Medak Exercises and Rebound Exercises—to see which one better improves physical fitness in children with Down syndrome. About 22 kids aged 3 to 8 will take part in 12 weeks of supervised sessions. The goal is to find a fun and effe…

This study tests whether using a powerball (a small exercise ball) on a stable surface or on an unstable surface (BOSU ball) can improve upper limb endurance and coordination in children with Down Syndrome. Twenty-eight children aged 6-10 will do 30-minute sessions three times a …

This study tests whether Vojta therapy, a technique that involves gentle stimulation of specific body zones, can improve how children with Down syndrome walk and move. Twenty-eight children aged 2 to 10 will be randomly assigned to receive either Vojta therapy or no extra therapy…

This natural history study will follow 700 people with Down syndrome and their healthy relatives for up to 15 years. Researchers want to learn how removing part of the thymus during heart surgery affects the immune system over time. Participants will have yearly check-ups, blood …

This study looks at how certain brain cells (cholinergic neurons) change with age in adults with Down syndrome, and how that relates to Alzheimer's disease risk. Researchers will use brain scans and EEGs to measure these changes in 30 adults aged 18-55 who do not have dementia. T…

This study looks at how using very short, simple sentences (like single words or telegraphic speech) affects how young children with Down syndrome process language and learn new words. Researchers will show children pictures and play recordings of different types of sentences to …

This study looks at blood vessel health in adults with Down syndrome (ages 18-35) compared to adults without Down syndrome. Researchers want to find out if people with Down syndrome have hidden changes in their blood vessels that could raise their risk for heart disease or stroke…

This long-term study will follow up to 1,400 people with Down syndrome of all ages to better understand their health, development, and daily experiences. Participants and their caregivers will answer questions, share medical records, and may provide blood or saliva samples. Some …

This study enrolls adults with Down syndrome ages 25-55 into a ready-to-test group. Researchers will track memory, thinking, and brain changes over time to better understand how Alzheimer's disease develops in this population. The goal is to make future clinical trials faster and…

This study looks at how the autonomic nervous system—which controls heart rate and blood pressure—works in people with Down syndrome. Researchers will measure stress responses using virtual reality, cold water, pain patches, caffeine, and exercise in 200 participants. The goal is…

This study looks at the long-term health of people with Down syndrome who have been treated for acute leukemia. Researchers want to understand what chronic health problems survivors may face and what factors contribute to them. The goal is to create better follow-up care guidelin…

This study looks at medical records of 1000 children with conditions like autism, epilepsy, and Down syndrome to find common biological patterns. Researchers want to understand what causes these disorders and how children respond to treatments. The goal is to improve diagnosis an…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study explores whether a non-invasive method using light, sound, and vibration can safely change brain activity in adults with Down syndrome. Researchers will measure brain waves and check for side effects during a single 30-60 minute session. The goal is to see if this appr…

This study uses non-invasive eye scans (OCT and OCTA) to look for changes in the retina that might be linked to brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers aim to find early markers that could help diagnose or track these conditions. The stud…

This study looks at children with Down Syndrome who have pneumonia to see if there is a link between their immune system and how well they breathe. Researchers will measure immune markers in the blood and breathing rate and oxygen levels. The goal is to better understand these re…

This study looks at how hearing sensitivity (hyperacusis) might help language skills in children and adults with Williams syndrome. Researchers will use EEG and NIRS brain scans along with questionnaires to compare participants with Williams syndrome, Down syndrome, and typical d…

This study creates a large collection of blood, saliva, urine, and other samples from 2,500 people with and without Down syndrome. The goal is to help researchers better understand Down syndrome and its related medical conditions. Participants must be between 6 months and 89 year…