DOWN SYNDROME

This study is testing if adding the drug nivolumab to a standard immunotherapy (blinatumomab) works better for controlling B-cell acute lymphoblastic leukemia (B-ALL) that has come back after initial treatment. It is for children and young adults aged 1 to 31 who have had their f…

This study is testing whether gentle light and sound stimulation can improve brain activity in adults with Down Syndrome. Researchers want to see if this non-invasive approach, which showed promise in Alzheimer's research, can help regulate brain waves and potentially slow future…

This study is testing whether a small, flexible nasal tube can help children with weak throat muscles breathe better during sleep. Researchers want to see if this device reduces sleep apnea episodes and improves sleep quality for children who have trouble with airway blockage. Th…

This study is testing if a personalized surgical approach works better than the standard surgery for treating obstructive sleep apnea (OSA) in children with Down syndrome. Researchers will use a special sleep scope to see exactly where a child's airway is blocked and then plan a …

This study is testing whether a medication called levetiracetam, commonly used for seizures, can prevent epileptic seizures in adults with Down syndrome who also have Alzheimer's disease. Researchers also want to see if the drug can slow down the brain changes and memory loss lin…

This is the first study in people to test the safety of an experimental oral drug called Leucettinib-21. It will first be given to healthy volunteers to check for side effects and how the body processes it. Later, a single dose will be given to a small group of men with Down synd…

This study is testing whether a weight loss program can help prevent or delay Alzheimer's disease in adults with Down syndrome. 81 adults with Down syndrome who are overweight but do not have dementia will be assigned to either a weight loss group or a general health education gr…

This study is testing whether Vojta therapy, a specific physical therapy approach, can improve walking and overall movement abilities in children with Down syndrome. It involves 28 children aged 2-10 who can stand and walk independently. Children will be randomly assigned to rece…

This study is testing if a specific arm exercise using a powerball device is more effective when done on a stable surface or a wobbly one. It involves 28 children with Down syndrome, aged 6-10, who will do the exercises three times a week for three weeks. The goal is to see which…

This study is testing a 16-week physical activity program called PACE for adults with intellectual disabilities. The program includes weekly group fitness classes, coaching sessions, and online resources. Researchers want to see if it helps participants become more active, improv…

This study aims to see which of two exercise programs works better to improve physical fitness in young children with Down syndrome. Researchers will compare Cuevas Medek Exercises, which focus on balance and posture, with Rebound Exercises, which use a small trampoline. The stud…

This study is testing whether adding jumping rope to play activities can help improve foot posture in children with Down syndrome. Researchers will work with 32 children aged 4-15 who have a specific foot condition called navicular drop. One group will do jumping rope plus play a…

This study aims to understand the long-term health effects of childhood leukemia treatment in people with Down syndrome. Researchers will compare 330 survivors with Down syndrome who had leukemia to similar individuals without cancer history. By identifying health risks and quali…

This study aims to understand how the immune system works and ages in people with Down syndrome over 15 years. It will follow 700 participants, including those who had their thymus gland removed during heart surgery as infants and those who did not. By collecting health data and …

This study is creating a large collection of biological samples and health information from people with and without Down syndrome. The goal is to provide approved researchers with materials to study conditions linked to Down syndrome, like heart defects, Alzheimer's, and leukemia…

This study aims to see if detailed pictures of the back of the eye (the retina) can reveal early signs of brain diseases like Alzheimer's and Parkinson's. Researchers will use special, non-invasive camera scans on 2000 people, both with and without these conditions. The goal is t…

This study aims to understand the relationship between the immune system and breathing in children with Down Syndrome who have pneumonia. Researchers will measure immune markers in the blood and breathing rates in 40 children. The goal is to gather knowledge, not to test a new tr…