15-Year study to uncover how thymus removal affects immune health in down syndrome
NCT ID NCT07416201
First seen Jun 26, 2026 · Last updated Jul 17, 2026 · Updated 3 times
Summary
This natural history study will follow 700 people with Down syndrome and their healthy relatives for up to 15 years. Researchers want to learn how removing part of the thymus during heart surgery affects the immune system over time. Participants will have yearly check-ups, blood and stool tests, and heart and lung function tests. The goal is to better understand infections, autoimmune problems, and blood diseases in this population.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
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