Scientists probe why hearts of people with down syndrome react differently to stress
NCT ID NCT07238465
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at how the autonomic nervous system—which controls heart rate and blood pressure—works in people with Down syndrome. Researchers will measure stress responses using virtual reality, cold water, pain patches, caffeine, and exercise in 200 participants. The goal is to understand why people with Down syndrome often have a blunted heart rate response during activity, which may affect their physical fitness and overall health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could reveal why people with Down syndrome often have lower exercise capacity, pointing toward future therapies to improve heart health and quality of life.
What could go wrong
This is an observational study, not a treatment trial. It will not directly improve health, and results may not lead to new therapies for years, if at all.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••