DOWN SYNDROME

This study tests a combination of two drugs (atomoxetine and oxybutynin) given at bedtime to children with Down syndrome who have obstructive sleep apnea. The goal is to see if the treatment improves breathing during sleep and thinking skills. Thirty-six children aged 6 to 17 wil…

This large phase 3 study tests whether adding the drug blinatumomab to standard chemotherapy helps prevent cancer from returning in children and young adults with newly diagnosed B-cell leukemia or lymphoma, including those with Down syndrome. About 6,720 participants receive tre…

This study tests a device that stimulates a nerve in the tongue to treat sleep apnea in 57 teens and young adults (ages 10-21) with Down syndrome. The goal is to see if treating sleep apnea this way improves thinking, attention, memory, and language skills over 12 months. Partici…

This study is testing a modified chemotherapy plan for children with Down syndrome who have newly diagnosed acute lymphoblastic leukemia (ALL). The treatment uses lower doses of certain drugs to reduce side effects while still fighting the cancer. About 60 children across Asia ar…

This study tests three medications—lorazepam, IVIG, and tofacitinib—in 66 people with Down syndrome (ages 8-30) who have developed a serious condition called Down Syndrome Regression Disorder (DSRD). DSRD causes sudden loss of skills, catatonia, and other severe symptoms. The goa…

This large phase 3 study is testing different combinations and doses of chemotherapy drugs in over 9,000 children and young adults newly diagnosed with standard-risk B-cell acute lymphoblastic leukemia or localized B-cell lymphoblastic lymphoma. The goal is to find which treatmen…

This study explores whether short video clips recorded by parents on their smartphones can help identify children with Down syndrome who are at high risk for obstructive sleep apnea (OSA). About 141 children will participate. Parents will record their child sleeping and then gues…

This study compares a new therapy—combining mild brain stimulation (tDCS) with virtual reality exercises—against standard physical therapy for 30 children aged 6-12 with Down syndrome. The goal is to see if the new approach improves balance, walking, thinking, and daily function.…

This study looks at whether a set of thinking and attention tests can measure changes caused by a stimulant medication in children aged 6 to 17 who have both intellectual disability and ADHD. About 68 participants will receive either the medication or a placebo, then switch after…

This study looks at whether a special resistance training program (called RESID) can help adults with Down syndrome age better. 36 adults aged 20-45 with mild to moderate intellectual disability will take part. Researchers will measure memory, strength, mobility, and well-being t…

This study checks if simple sleep questionnaires can accurately detect obstructive sleep apnea in children with Down syndrome, who are at higher risk. About 81 children aged 2-17 will answer sleep questions and have their results compared to a standard overnight sleep test. The g…

This study aims to find out how often children with Down syndrome have neck spine problems, what symptoms they show, and what X-rays reveal. Researchers will study 50 children aged 2 to 18 at Sohag University Hospital. The goal is to better understand these spine issues so doctor…

This study aims to create a computer model that predicts how airway surgery will affect obstructive sleep apnea (OSA) in children with Down syndrome. Researchers will measure airway resistance during sleep MRI scans in about 73 participants. The goal is to better plan surgeries a…