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Promising combo therapy aims to beat back childhood blood cancers

NCT ID NCT03914625

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This large phase 3 study tests whether adding the drug blinatumomab to standard chemotherapy can improve outcomes for children and young adults with newly diagnosed B-cell acute lymphoblastic leukemia or lymphoma, including those with Down syndrome. The trial enrolls over 6,700 participants and tailors treatment based on risk of relapse. The goal is to see if the combination helps keep cancer from coming back.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 6,720 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2019

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

365 days to 31 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All B-ALL patients must be enrolled on APEC14B1 and consented to Eligibility Screening (Part A) prior to treatment and enrollment on AALL1731. APEC 14B1 is not a requirement for B-LLy patients. B-LLy patients may directly enroll on AALL1731. * Age at diagnosis: * Patients must be \>= 365 days and \< 10 years of age (B-ALL patients without DS). * Patients must be \>= 365 days and =\< 31 years of age (B-ALL patients with DS). * Patients must be \>= 365 days and =\< 31 years of age (B-LLy patients with or without DS). * B-ALL patients without DS must have an initial white blood cell count \< 50,000/uL (performed within 7 days prior to enrollment). * B-ALL patients with DS are eligible regardless of the presenting white blood cell count (WBC) (performed within 7 days prior to enrollment). * Patient has newly diagnosed B-cell ALL, with or without Down syndrome: \> 25% blasts on a bone marrow (BM) aspirate; * OR if a BM aspirate is not obtained or is not diagnostic of B-ALL, the diagnosis can be established by a pathologic diagnosis of B-ALL on a BM biopsy; * OR a complete blood count (CBC) documenting the presence of at least 1,000/uL circulating leukemic cells; * OR patient has newly diagnosed B-cell LLy Murphy stages I or II, with or without Down syndrome. * Note: For B-LLy patients with tissue available for flow cytometry, the criterion for diagnosis should be analogous to B-ALL. For tissue processed by other means (i.e., paraffin blocks), the methodology and criteria for immunophenotypic analysis to establish the diagnosis of B-LLy defined by the submitting institution will be accepted (diagnostic biopsy for B-LLy must be performed within 14 days prior to enrollment). * All patients and/or their parents or legal guardians must sign a written informed consent. * All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met. Exclusion Criteria: * Patient must not have secondary ALL that developed after treatment of a prior malignancy with cytotoxic chemotherapy. Note: patients with Down syndrome with a prior history of transient myeloproliferative disease (TMD) are not considered to have had a prior malignancy. They would therefore be eligible whether or not the TMD was treated with cytarabine. * With the exception of steroid pretreatment or the administration of intrathecal cytarabine, patients must not have received any prior cytotoxic chemotherapy for either the current diagnosis of B ALL or B LLy or for any cancer diagnosed prior to initiation of protocol therapy on AALL1731. * For patients receiving steroid pretreatment, the following additional exclusion criteria apply: * Non-DS B-ALL patients must not have received steroids for more than 24 hours in the 2 weeks prior to diagnosis without a CBC obtained within 3 days prior to initiation of the steroids. * DS and non-DS B-LLy patients must not have received \> 48 hours of oral or IV steroids within 4 weeks of diagnosis. * Patients who have received \> 72 hours of hydroxyurea within 1 week (7 days) prior to the start of systemic protocol therapy. * B-ALL patients who do not have sufficient diagnostic bone marrow submitted for APEC14B1 diagnostic testing and who do not have a peripheral blood sample submitted containing \> 1,000/uL circulating leukemia cells. * Patient must not have acute undifferentiated leukemia (AUL). * Non-DS B-ALL patients with central nervous system \[CNS\]3 leukemia (CNS status must be known prior to enrollment). * Note: DS patients with CNS3 disease are eligible but will be assigned to the DS-High B-ALL arm. CNS status must be determined based on a sample obtained prior to administration of any systemic or intrathecal chemotherapy, except for steroid pretreatment. * Non-DS B-ALL patients with testicular leukemia. (Note: DS patients with testicular disease are eligible but will be assigned to the DS-High B-ALL arm). * For LLy patients, the following additional exclusion criteria apply: * T-Lymphoblastic Lymphoma. * Morphologically unclassifiable lymphoma. * Absence of both B-cell and T-cell phenotype markers in a case submitted as lymphoblastic lymphoma. * CNS positive disease or testicular involvement. * M2 (5% - 25% blasts) or M3 (\> 25% blasts) marrow. * Patients with known Charcot-Marie-Tooth disease. * Patients with known MYC translocation associated with mature (Burkitt) B-cell ALL, regardless of blast immunophenotype. * Patients requiring radiation at diagnosis. * Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs. A pregnancy test is required for female patients of childbearing potential. * Lactating females who plan to breastfeed their infants. * Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of their study participation.

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Conditions

The condition(s) this trial relates to.

B-cell acute lymphoblastic leukemia B-cell childhood acute lymphoblastic leukemia Burkitt lymphoma Down syndrome lymphoblastic lymphoma precursor B-cell acute lymphoblastic leukemia Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B acute lymphoblastic leukemia B lymphoblastic lymphoma Down syndrome

Contacts and locations

Locations

  • AdventHealth Orlando

    Orlando, Florida, 32803, United States

  • Advocate Children's Hospital-Oak Lawn

    Oak Lawn, Illinois, 60453, United States

  • Advocate Children's Hospital-Park Ridge

    Park Ridge, Illinois, 60068, United States

  • Albany Medical Center

    Albany, New York, 12208, United States

  • Alberta Children's Hospital

    Calgary, Alberta, T3B 6A8, Canada

  • Alfred I duPont Hospital for Children

    Wilmington, Delaware, 19803, United States

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    Las Vegas, Nevada, 89135, United States

  • Arkansas Children's Hospital

    Little Rock, Arkansas, 72202-3591, United States

  • Arnold Palmer Hospital for Children

    Orlando, Florida, 32806, United States

  • Ascension Saint Vincent Indianapolis Hospital

    Indianapolis, Indiana, 46260, United States

  • Atrium Health Navicent

    Macon, Georgia, 31201, United States

  • Augusta University Medical Center

    Augusta, Georgia, 30912, United States

  • BI-LO Charities Children's Cancer Center

    Greenville, South Carolina, 29605, United States

  • Banner Children's at Desert

    Mesa, Arizona, 85202, United States

  • Banner University Medical Center - Tucson

    Tucson, Arizona, 85719, United States

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas, 77030, United States

  • Baystate Medical Center

    Springfield, Massachusetts, 01199, United States

  • Blank Children's Hospital

    Des Moines, Iowa, 50309, United States

  • British Columbia Children's Hospital

    Vancouver, British Columbia, V6H 3V4, Canada

  • Bronson Methodist Hospital

    Kalamazoo, Michigan, 49007, United States

  • Broward Health Medical Center

    Fort Lauderdale, Florida, 33316, United States

  • C S Mott Children's Hospital

    Ann Arbor, Michigan, 48109, United States

  • CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

    Québec, G1V 4G2, Canada

  • CancerCare Manitoba

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Cardinal Glennon Children's Medical Center

    St Louis, Missouri, 63104, United States

  • Carilion Children's

    Roanoke, Virginia, 24014, United States

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina, 28203, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia, 30329, United States

  • Children's Hospital

    London, Ontario, N6A 5W9, Canada

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Children's Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Children's Hospital Medical Center of Akron

    Akron, Ohio, 44308, United States

  • Children's Hospital New Orleans

    New Orleans, Louisiana, 70118, United States

  • Children's Hospital and Medical Center of Omaha

    Omaha, Nebraska, 68114, United States

  • Children's Hospital of Alabama

    Birmingham, Alabama, 35233, United States

  • Children's Hospital of Eastern Ontario

    Ottawa, Ontario, K1H 8L1, Canada

  • Children's Hospital of Michigan

    Detroit, Michigan, 48201, United States

  • Children's Hospital of Orange County

    Orange, California, 92868, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Hospital of Pittsburgh of UPMC

    Pittsburgh, Pennsylvania, 15224, United States

  • Children's Hospital of San Antonio

    San Antonio, Texas, 78207, United States

  • Children's Hospital of The King's Daughters

    Norfolk, Virginia, 23507, United States

  • Children's Hospital of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Children's Hospitals and Clinics of Minnesota - Minneapolis

    Minneapolis, Minnesota, 55404, United States

  • Children's Mercy Hospitals and Clinics

    Kansas City, Missouri, 64108, United States

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010, United States

  • Christchurch Hospital

    Christchurch, 8011, New Zealand

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Connecticut Children's Medical Center

    Hartford, Connecticut, 06106, United States

  • Cook Children's Medical Center

    Fort Worth, Texas, 76104, United States

  • Corewell Health Children's

    Royal Oak, Michigan, 48073, United States

  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

    Grand Rapids, Michigan, 49503, United States

  • Covenant Children's Hospital

    Lubbock, Texas, 79410, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire, 03756, United States

  • Dayton Children's Hospital

    Dayton, Ohio, 45404, United States

  • Dell Children's Medical Center of Central Texas

    Austin, Texas, 78723, United States

  • Driscoll Children's Hospital

    Corpus Christi, Texas, 78411, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • East Carolina University

    Greenville, North Carolina, 27834, United States

  • East Tennessee Childrens Hospital

    Knoxville, Tennessee, 37916, United States

  • Eastern Maine Medical Center

    Bangor, Maine, 04401, United States

  • Edwards Comprehensive Cancer Center

    Huntington, West Virginia, 25701, United States

  • El Paso Children's Hospital

    El Paso, Texas, 79905, United States

  • Geisinger Medical Center

    Danville, Pennsylvania, 17822, United States

  • Golisano Children's Hospital of Southwest Florida

    Fort Myers, Florida, 33908, United States

  • HIMA San Pablo Oncologic Hospital

    Caguas, 00726, Puerto Rico

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Henry Ford Health Saint John Hospital

    Detroit, Michigan, 48236, United States

  • Hospital for Sick Children

    Toronto, Ontario, M5G 1X8, Canada

  • IWK Health Centre

    Halifax, Nova Scotia, B3K 6R8, Canada

  • Inova Fairfax Hospital

    Falls Church, Virginia, 22042, United States

  • Janeway Child Health Centre

    St. John's, Newfoundland and Labrador, A1B 3V6, Canada

  • Jersey Shore Medical Center

    Neptune City, New Jersey, 07753, United States

  • Jim Pattison Children's Hospital

    Saskatoon, Saskatchewan, S7N 0W8, Canada

  • John Hunter Children's Hospital

    Hunter Regional Mail Centre, New South Wales, 2310, Australia

  • Johns Hopkins All Children's Hospital

    St. Petersburg, Florida, 33701, United States

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287, United States

  • Kaiser Permanente Downey Medical Center

    Downey, California, 90242, United States

  • Kaiser Permanente-Oakland

    Oakland, California, 94611, United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, 96826, United States

  • Kingston Health Sciences Centre

    Kingston, Ontario, K7L 2V7, Canada

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    New York, New York, 10016, United States

  • Legacy Emanuel Children's Hospital

    Portland, Oregon, 97227, United States

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania, 18103, United States

  • Loma Linda University Medical Center

    Loma Linda, California, 92354, United States

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • Lucile Packard Children's Hospital Stanford University

    Palo Alto, California, 94304, United States

  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

    Torrance, California, 90502, United States

  • Lurie Children's Hospital-Chicago

    Chicago, Illinois, 60611, United States

  • Madigan Army Medical Center

    Tacoma, Washington, 98431, United States

  • Maimonides Medical Center

    Brooklyn, New York, 11219, United States

  • Maine Children's Cancer Program

    Scarborough, Maine, 04074, United States

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449, United States

  • Mary Bridge Children's Hospital and Health Center

    Tacoma, Washington, 98405, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, 02114, United States

  • Mattel Children's Hospital UCLA

    Los Angeles, California, 90095, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • McMaster Children's Hospital at Hamilton Health Sciences

    Hamilton, Ontario, L8N 3Z5, Canada

  • MedStar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

  • Medical City Dallas Hospital

    Dallas, Texas, 75230, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Memorial Health University Medical Center

    Savannah, Georgia, 31404, United States

  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital

    Hollywood, Florida, 33021, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141, United States

  • Methodist Children's Hospital of South Texas

    San Antonio, Texas, 78229, United States

  • Miami Cancer Institute

    Miami, Florida, 33176, United States

  • Michigan State University

    East Lansing, Michigan, 48823, United States

  • Miller Children's and Women's Hospital Long Beach

    Long Beach, California, 90806, United States

  • Mission Hospital

    Asheville, North Carolina, 28801, United States

  • Monash Medical Center-Clayton Campus

    Clayton, Victoria, 3168, Australia

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York, 10467, United States

  • Morristown Medical Center

    Morristown, New Jersey, 07960, United States

  • Mount Sinai Hospital

    New York, New York, 10029, United States

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    New York, New York, 10032, United States

  • NYP/Weill Cornell Medical Center

    New York, New York, 10065, United States

  • NYU Langone Hospital - Long Island

    Mineola, New York, 11501, United States

  • Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

  • Naval Medical Center - Portsmouth

    Portsmouth, Virginia, 23708-2197, United States

  • Naval Medical Center -San Diego

    San Diego, California, 92134, United States

  • Nemours Children's Clinic-Jacksonville

    Jacksonville, Florida, 32207, United States

  • Nemours Children's Hospital

    Orlando, Florida, 32827, United States

  • New York Medical College

    Valhalla, New York, 10595, United States

  • Newark Beth Israel Medical Center

    Newark, New Jersey, 07112, United States

  • Nicklaus Children's Hospital

    Miami, Florida, 33155, United States

  • Northwestern Medicine Central DuPage Hospital

    Winfield, Illinois, 60190, United States

  • Norton Children's Hospital

    Louisville, Kentucky, 40202, United States

  • Novant Health Presbyterian Medical Center

    Charlotte, North Carolina, 28204, United States

  • OSF Children's Hospital of Illinois

    Peoria, Illinois, 61637, United States

  • Ochsner Medical Center Jefferson

    New Orleans, Louisiana, 70121, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Palms West Radiation Therapy

    Loxahatchee Groves, Florida, 33470, United States

  • Penn State Children's Hospital

    Hershey, Pennsylvania, 17033, United States

  • Perth Children's Hospital

    Perth, Western Australia, 6009, Australia

  • Phoenix Childrens Hospital

    Phoenix, Arizona, 85016, United States

  • Presbyterian Hospital

    Albuquerque, New Mexico, 87106, United States

  • Primary Children's Hospital

    Salt Lake City, Utah, 84113, United States

  • Prisma Health Richland Hospital

    Columbia, South Carolina, 29203, United States

  • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

    Toledo, Ohio, 43606, United States

  • Providence Alaska Medical Center

    Anchorage, Alaska, 99508, United States

  • Providence Sacred Heart Medical Center and Children's Hospital

    Spokane, Washington, 99204, United States

  • Queensland Children's Hospital

    South Brisbane, Queensland, 4101, Australia

  • Rady Children's Hospital - San Diego

    San Diego, California, 92123, United States

  • Rainbow Babies and Childrens Hospital

    Cleveland, Ohio, 44106, United States

  • Renown Regional Medical Center

    Reno, Nevada, 89502, United States

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Riley Hospital for Children

    Indianapolis, Indiana, 46202, United States

  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

    Denver, Colorado, 80218, United States

  • Royal Children's Hospital

    Parkville, Victoria, 3052, Australia

  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

    New Brunswick, New Jersey, 08903, United States

  • Sacred Heart Hospital

    Pensacola, Florida, 32504, United States

  • Saint Christopher's Hospital for Children

    Philadelphia, Pennsylvania, 19134, United States

  • Saint Francis Children's Hospital

    Tulsa, Oklahoma, 74136, United States

  • Saint Joseph's Hospital/Children's Hospital-Tampa

    Tampa, Florida, 33607, United States

  • Saint Joseph's Regional Medical Center

    Paterson, New Jersey, 07503, United States

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho, 83712, United States

  • Saint Mary's Medical Center

    West Palm Beach, Florida, 33407, United States

  • Saint Peter's University Hospital

    New Brunswick, New Jersey, 08901, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    Green Bay, Wisconsin, 54301, United States

  • Sanford Broadway Medical Center

    Fargo, North Dakota, 58122, United States

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Santa Barbara Cottage Hospital

    Santa Barbara, California, 93102, United States

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan, S7N 4H4, Canada

  • Scott and White Memorial Hospital

    Temple, Texas, 76508, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • Sinai Hospital of Baltimore

    Baltimore, Maryland, 21215, United States

  • Southern Illinois University School of Medicine

    Springfield, Illinois, 62702, United States

  • Starship Children's Hospital

    Grafton, Auckland, 1145, New Zealand

  • State University of New York Upstate Medical University

    Syracuse, New York, 13210, United States

  • Stony Brook University Medical Center

    Stony Brook, New York, 11794, United States

  • Summerlin Hospital Medical Center

    Las Vegas, Nevada, 89144, United States

  • Sunrise Hospital and Medical Center

    Las Vegas, Nevada, 89109, United States

  • Sutter Medical Center Sacramento

    Sacramento, California, 95816, United States

  • T C Thompson Children's Hospital

    Chattanooga, Tennessee, 37403, United States

  • Tampa General Hospital

    Tampa, Florida, 33606, United States

  • Texas Tech University Health Sciences Center-Amarillo

    Amarillo, Texas, 79106, United States

  • The Children's Hospital at TriStar Centennial

    Nashville, Tennessee, 37203, United States

  • The Children's Hospital at Westmead

    Westmead, New South Wales, 2145, Australia

  • The Montreal Children's Hospital of the MUHC

    Montreal, Quebec, H3H 1P3, Canada

  • The Steven and Alexandra Cohen Children's Medical Center of New York

    New Hyde Park, New York, 11040, United States

  • Tripler Army Medical Center

    Honolulu, Hawaii, 96859, United States

  • Tufts Children's Hospital

    Boston, Massachusetts, 02111, United States

  • UCSF Benioff Children's Hospital Oakland

    Oakland, California, 94609, United States

  • UCSF Medical Center-Mission Bay

    San Francisco, California, 94158, United States

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida, 32610, United States

  • UMC Cancer Center / UMC Health System

    Lubbock, Texas, 79415, United States

  • UMass Memorial Medical Center - University Campus

    Worcester, Massachusetts, 01655, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • USA Health Strada Patient Care Center

    Mobile, Alabama, 36604, United States

  • UT MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • University Medical Center of Southern Nevada

    Las Vegas, Nevada, 89102, United States

  • University Pediatric Hospital

    San Juan, 00926, Puerto Rico

  • University of Alberta Hospital

    Edmonton, Alberta, T6G 2B7, Canada

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, 60637, United States

  • University of Illinois

    Chicago, Illinois, 60612, United States

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa, 52242, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland, 21201, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, 33136, United States

  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota, 55455, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216, United States

  • University of Missouri Children's Hospital

    Columbia, Missouri, 65212, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, 87106, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas, 78229, United States

  • University of Vermont and State Agricultural College

    Burlington, Vermont, 05405, United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22908, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin, 53792, United States

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia, 23298, United States

  • Valley Children's Hospital

    Madera, California, 93636, United States

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

  • Vannie Cook Children's Clinic

    McAllen, Texas, 78503, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Walter Reed National Military Medical Center

    Bethesda, Maryland, 20889-5600, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • West Virginia University Charleston Division

    Charleston, West Virginia, 25304, United States

  • West Virginia University Healthcare

    Morgantown, West Virginia, 26506, United States

  • Women's and Children's Hospital-Adelaide

    North Adelaide, South Australia, 5006, Australia

  • Yale University

    New Haven, Connecticut, 06520, United States

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