B ACUTE LYMPHOBLASTIC LEUKEMIA

This study aims to see if adding a nutrient supplement called levocarnitine to standard chemotherapy can protect the liver in adolescents and young adults (ages 15-39) being treated for leukemia or lymphoma. A key chemotherapy drug, asparaginase, often causes severe liver damage …

This is an early-phase study testing the safety and initial effectiveness of a new type of CAR-T cell therapy for adults with relapsed or hard-to-treat blood cancers, including certain leukemias and lymphomas. Participants will receive a single infusion of these specially enginee…

This study is testing the safety and best dose of a drug called venetoclax when added to a standard, intensive chemotherapy regimen for adults newly diagnosed with a type of blood cancer called B-cell acute lymphoblastic leukemia. The goal is to see if this combination can be tol…

This study is testing whether giving blood transfusions at a lower hemoglobin level (7 gm/dL) works as well as giving them at a higher level (9 gm/dL) for leukemia patients after chemotherapy or stem cell transplant. Researchers want to see if the lower level maintains patients' …

This study is testing whether adding two newer drugs, blinatumomab and venetoclax, to standard chemotherapy works better for babies under one year old with a rare and aggressive type of blood cancer called acute lymphoblastic leukemia (ALL). The main goal is to see if these combi…

This large study is testing if adding a targeted drug called inotuzumab ozogamicin to standard chemotherapy and immunotherapy improves long-term survival for children and young adults with high-risk B-cell acute lymphoblastic leukemia (B-ALL). It will also track outcomes for pati…

This study is testing if a new combination of standard chemotherapy and two newer immunotherapy drugs works better as a first treatment for adults with B-cell acute lymphoblastic leukemia (ALL). The goal is to see if this approach helps patients stay cancer-free longer. The trial…

This international Phase 3 trial is testing whether adding an immunotherapy drug called blinatumomab to standard chemotherapy and targeted drugs works better for young people (under 25) with specific, hard-to-treat types of B-cell acute lymphoblastic leukemia. The goal is to impr…

This early-stage study is testing the safety and best dose of a new combination of oral pills (venetoclax and dasatinib) for adults with a specific, aggressive type of blood cancer called Philadelphia chromosome positive acute lymphoblastic leukemia (ALL) or mixed phenotype acute…