DOWN SYNDROME
Clinical trials for DOWN SYNDROME explained in plain language.
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Early safety trial of ION269 for Alzheimer's in down syndrome ends after just one participant
Disease control TerminatedThis early-stage study tested a drug called ION269 in adults with Down syndrome who also showed signs of Alzheimer's disease. The goal was to check if the drug was safe and tolerable when injected into the spinal fluid. Only one person took part, and the study was stopped early, …
Matched conditions: DOWN SYNDROME
Phase: PHASE1 • Sponsor: Ionis Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Down syndrome hyperactivity drug trial stalls after just 3 kids enrolled
Symptom relief TerminatedThis study tested the drug guanfacine to see if it could reduce hyperactivity and impulsivity in children aged 6 to 12 with Down syndrome. The plan was to give the drug or a placebo for 8 weeks and measure behavior changes. However, the trial was stopped early after only 3 childr…
Matched conditions: DOWN SYNDROME
Phase: PHASE2 • Sponsor: Rachel G. Greenberg, MD, MB, MHS • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC