Down syndrome hyperactivity drug trial stalls after just 3 kids enrolled

NCT ID NCT06042257

Terminated Symptom relief Sponsor: Rachel G. Greenberg, MD, MB, MHS Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested the drug guanfacine to see if it could reduce hyperactivity and impulsivity in children aged 6 to 12 with Down syndrome. The plan was to give the drug or a placebo for 8 weeks and measure behavior changes. However, the trial was stopped early after only 3 children joined, so we don't have enough data to know if it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Guanfacine (immediate-release capsules)
What this could lead to: If it had worked, this could have pointed toward a medication to ease hyperactivity and impulsivity in children with Down syndrome.
What could go wrong: The trial was terminated early with only 3 participants, so no reliable conclusions can be drawn. Guanfacine may also cause side effects like drowsiness or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Down syndrome Impulsive Behavior Spasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERACTIVITY IN CHILDREN WITH DOWN SYNDROME IMPULSIVITY IN CHILDREN WITH DOWN SYNDROME

Contacts and locations

Locations

Akron Children's Hospital

Akron, Ohio, 44308, United States
Ann and Robert H. Lurie Hospital of Chicago

Chicago, Illinois, 60611, United States
Atrium Health-Wake Forest School of Medicine

Charlotte, North Carolina, 28204, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Cincinnati Children's Hospital

Cincinnati, Ohio, 45229, United States
Duke University Hospital

Durham, North Carolina, 27705, United States
Emory University

Atlanta, Georgia, 30322, United States
Kennedy Krieger Institute

Baltimore, Maryland, 21205, United States
Massachusetts General Hospital

Lexington, Massachusetts, 02421, United States
Phoenix Childrens Hospital

Phoenix, Arizona, 85016, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Washington

Seattle, Washington, 98195, United States
University of Wisconsin Madison

Madison, Wisconsin, 53792, United States
Virginia Center for Children

Richmond, Virginia, 23220, United States

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