Massive study aims to crack the code on Kids' medications

NCT ID NCT04278404

Recruiting now Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe the safest and most effective doses. The study covers many conditions, from COVID-19 to heart failure, and includes drugs like antibiotics, pain relievers, and heart medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Various drugs (e.g., amiodarone, furosemide, oxycodone, metformin) given as part of standard care
What this could lead to: If successful, this could help doctors determine the safest and most effective doses of common drugs for children, improving pediatric care.
What could go wrong: This is an observational study collecting data from routine care, not testing new treatments. Results may take years to influence practice and may not apply to all children.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

adrenocortical insufficiency Arrhythmias, Cardiac attention deficit hyperactivity disorder, inattentive type attention deficit-hyperactivity disorder blood coagulation disease bronchopulmonary dysplasia cardiac rhythm disease cellulitis childhood onset asthma Coronavinae infectious disease COVID-19 COVID-19–associated multisystem inflammatory syndrome in children Down syndrome Edema heart failure hemophilia hemophilia A Hemorrhage hyperaldosteronism hyperphosphatemia hypertensive disorder insomnia Kawasaki disease Menorrhagia Pain pediatric multisystem inflammatory disease, COVID-19 related pneumonia potassium deficiency disease pulmonary arterial hypertension skin infection urinary tract infection vascular hemostatic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADRENAL INSUFFICIENCY ARRYTHMIA ASTHMA IN CHILDREN ATTENTION DEFICIT HYPERACTIVITY DISORDER BRONCHOPULMONARY DYSPLASIA COAGULATION DISORDER CORONAVIRUS INFECTION (COVID-19) DOWN SYNDROME EDEMA FIBRINOLYSIS; HEMORRHAGE HEART FAILURE HEMOPHILIA HYPERPHOSPHATEMIA HYPERTENSION HYPOKALEMIA INSOMNIA KAWASAKI DISEASE MENORRHAGIA MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) PAIN PNEUMONIA PRIMARY HYPERALDOSTERONISM PULMONARY ARTERIAL HYPERTENSION SKIN INFECTION URINARY TRACT INFECTIONS IN CHILDREN

Contacts and locations

Locations

Alfred I. DuPont Hospital for Children
COMPLETED

Wilmington, Delaware, 19803, United States
Ann and Robert H. Lurie Childrens Hospital of Chicago
COMPLETED

Chicago, Illinois, 60611, United States
Ann and Robert H. Lurie Childrens Hospital of Chicago
RECRUITING

Chicago, Illinois, 60614, United States
Arkansas Children's Hospital Research Institute
RECRUITING

Little Rock, Arkansas, 72202, United States
Avera McKennan Hospital & University Medical Center
COMPLETED

Sioux Falls, South Dakota, 57108, United States
Board of Regents of the University of Oklahoma
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Boston Children's Hospital
COMPLETED

Boston, Massachusetts, 02115, United States
CHU Sainte-Justine
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
Children's Mercy Hospital
COMPLETED

Kansas City, Missouri, 64108, United States
Cincinnati Childrens Hospital Medical Center
COMPLETED

Cincinnati, Ohio, 45229, United States
Cincinnati Childrens Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
Colorado University Denver
RECRUITING

Aurora, Colorado, 80045, United States
Dartmouth-Hitchcock Medical Center
COMPLETED

Lebanon, New Hampshire, 03756, United States
Dell Children's Medical Center of Central Texas
RECRUITING

Austin, Texas, 78723, United States
Duke University Health System
RECRUITING

Durham, North Carolina, 27710, United States
Kapiolani Womens and Childrens Medical Center
RECRUITING

Honolulu, Hawaii, 96826, United States
Lucile Packard Children's Hospital
RECRUITING

Palo Alto, California, 94304, United States
Massachusetts General Hospital
COMPLETED

Lexington, Massachusetts, 02421, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina Children's Hospital
RECRUITING

Charleston, South Carolina, 29425, United States
Mississippi Center for Advanced Medicine
COMPLETED

Madison, Mississippi, 39110, United States
Monroe Carell Jr. Children's Hospital at Vanderbilt
RECRUITING

Nashville, Tennessee, 37232, United States
Ochsner Baptist Clinical Trials Unit
RECRUITING

New Orleans, Louisiana, 70115, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Pennsylvania State University--Hershey Children's Hospital
COMPLETED

Hershey, Pennsylvania, 17033, United States
Phoenix Children's Hospital
COMPLETED

Phoenix, Arizona, 85016, United States
Rhode Island Hospital
COMPLETED

Providence, Rhode Island, 02903, United States
Riley Hospital for Children at Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
The Children's Hospital Colorado
COMPLETED

Aurora, Colorado, 80045, United States
The Hospital for Sick Children
RECRUITING

Toronto, Ontario, Canada
The Womens Hospital of Texas
RECRUITING

Houston, Texas, 77054, United States
Tulane University Health Science Center
COMPLETED

New Orleans, Louisiana, 70112, United States
University Wisconsin Madison
COMPLETED

Madison, Wisconsin, 53705, United States
University of California, Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90095, United States
University of Florida Jacksonville Shands Medical Center
RECRUITING

Jacksonville, Florida, 32209, United States
University of Iowa Stead Family Children's Hospital
COMPLETED

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center-JG Kidney Institute
COMPLETED

Kansas City, Kansas, 66160, United States
University of Louisville Norton Childrens Hospital
RECRUITING

Louisville, Kentucky, 40202, United States
University of Maryland Medical Center
COMPLETED

Baltimore, Maryland, 21201, United States
University of Minnesota
COMPLETED

Minneapolis, Minnesota, 55455, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68114, United States
University of New Mexico Health Science Center
COMPLETED

Albuquerque, New Mexico, 87131, United States
University of North Carolina at Chapel Hill
COMPLETED

Chapel Hill, North Carolina, 27599, United States
University of South Carolina
COMPLETED

Columbia, South Carolina, 29208, United States
University of Texas--Memorial Hermann Texas Medical Center
COMPLETED

Houston, Texas, 77030, United States
University of Texas-Southwestern Medical Center Dallas
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75390, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84113, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53705, United States
West Virginia University Hospital
ACTIVE_NOT_RECRUITING

Morgantown, West Virginia, 26506, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.