Massive study aims to crack the code on Kids' medications
NCT ID NCT04278404
First seen Apr 20, 2026 · Last updated Jun 21, 2026 · Updated 9 times
Summary
This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe the safest and most effective doses. The study covers many conditions, from COVID-19 to heart failure, and includes drugs like antibiotics, pain relievers, and heart medications.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Alfred I. DuPont Hospital for Children
COMPLETEDWilmington, Delaware, 19803, United States
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Ann and Robert H. Lurie Childrens Hospital of Chicago
COMPLETEDChicago, Illinois, 60611, United States
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Ann and Robert H. Lurie Childrens Hospital of Chicago
RECRUITINGChicago, Illinois, 60614, United States
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Arkansas Children's Hospital Research Institute
RECRUITINGLittle Rock, Arkansas, 72202, United States
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Avera McKennan Hospital & University Medical Center
COMPLETEDSioux Falls, South Dakota, 57108, United States
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Board of Regents of the University of Oklahoma
RECRUITINGOklahoma City, Oklahoma, 73104, United States
Contact
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Boston Children's Hospital
COMPLETEDBoston, Massachusetts, 02115, United States
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CHU Sainte-Justine
RECRUITINGMontreal, Quebec, H3T 1C5, Canada
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Contact
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Children's Mercy Hospital
COMPLETEDKansas City, Missouri, 64108, United States
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Cincinnati Childrens Hospital Medical Center
COMPLETEDCincinnati, Ohio, 45229, United States
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Cincinnati Childrens Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Colorado University Denver
RECRUITINGAurora, Colorado, 80045, United States
Contact Email: •••••@•••••
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Dartmouth-Hitchcock Medical Center
COMPLETEDLebanon, New Hampshire, 03756, United States
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Dell Children's Medical Center of Central Texas
RECRUITINGAustin, Texas, 78723, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Duke University Health System
RECRUITINGDurham, North Carolina, 27710, United States
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Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kapiolani Womens and Childrens Medical Center
RECRUITINGHonolulu, Hawaii, 96826, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Lucile Packard Children's Hospital
RECRUITINGPalo Alto, California, 94304, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Massachusetts General Hospital
COMPLETEDLexington, Massachusetts, 02421, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Medical University of South Carolina Children's Hospital
RECRUITINGCharleston, South Carolina, 29425, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mississippi Center for Advanced Medicine
COMPLETEDMadison, Mississippi, 39110, United States
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Monroe Carell Jr. Children's Hospital at Vanderbilt
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ochsner Baptist Clinical Trials Unit
RECRUITINGNew Orleans, Louisiana, 70115, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oregon Health and Science University
RECRUITINGPortland, Oregon, 97239, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Pennsylvania State University--Hershey Children's Hospital
COMPLETEDHershey, Pennsylvania, 17033, United States
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Phoenix Children's Hospital
COMPLETEDPhoenix, Arizona, 85016, United States
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Rhode Island Hospital
COMPLETEDProvidence, Rhode Island, 02903, United States
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Riley Hospital for Children at Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Children's Hospital Colorado
COMPLETEDAurora, Colorado, 80045, United States
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The Hospital for Sick Children
RECRUITINGToronto, Ontario, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The Womens Hospital of Texas
RECRUITINGHouston, Texas, 77054, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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Tulane University Health Science Center
COMPLETEDNew Orleans, Louisiana, 70112, United States
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University Wisconsin Madison
COMPLETEDMadison, Wisconsin, 53705, United States
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University of California, Los Angeles Medical Center
RECRUITINGLos Angeles, California, 90095, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Florida Jacksonville Shands Medical Center
RECRUITINGJacksonville, Florida, 32209, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Iowa Stead Family Children's Hospital
COMPLETEDIowa City, Iowa, 52242, United States
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University of Kansas Medical Center-JG Kidney Institute
COMPLETEDKansas City, Kansas, 66160, United States
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University of Louisville Norton Childrens Hospital
RECRUITINGLouisville, Kentucky, 40202, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Maryland Medical Center
COMPLETEDBaltimore, Maryland, 21201, United States
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University of Minnesota
COMPLETEDMinneapolis, Minnesota, 55455, United States
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University of Mississippi Medical Center
RECRUITINGJackson, Mississippi, 39216, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of New Mexico Health Science Center
COMPLETEDAlbuquerque, New Mexico, 87131, United States
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University of North Carolina at Chapel Hill
COMPLETEDChapel Hill, North Carolina, 27599, United States
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University of South Carolina
COMPLETEDColumbia, South Carolina, 29208, United States
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University of Texas--Memorial Hermann Texas Medical Center
COMPLETEDHouston, Texas, 77030, United States
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University of Texas-Southwestern Medical Center Dallas
ACTIVE_NOT_RECRUITINGDallas, Texas, 75390, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84113, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Wisconsin
RECRUITINGMadison, Wisconsin, 53705, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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West Virginia University Hospital
ACTIVE_NOT_RECRUITINGMorgantown, West Virginia, 26506, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Various drugs (e.g., amiodarone, furosemide, oxycodone, metformin) given as part of standard care
What this could lead to
If successful, this could help doctors determine the safest and most effective doses of common drugs for children, improving pediatric care.
What could go wrong
This is an observational study collecting data from routine care, not testing new treatments. Results may take years to influence practice and may not apply to all children.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.