Adrenocortical insufficiency

This study is testing the long-term safety and effectiveness of a daily pill called atumelnant for people with classic congenital adrenal hyperplasia (CAH). The drug works by blocking a hormone receptor to help control excess androgen production. Researchers will monitor 150 part…

This study tests a daily oral medication called atumelnant in children aged 1 to 18 with classic congenital adrenal hyperplasia, a genetic condition that disrupts hormone production. The goal is to see if the drug can safely normalize hormone levels and allow patients to lower th…

This study tests a new drug, atumelnant, in 150 adults with classic congenital adrenal hyperplasia (CAH). The goal is to see if it can safely control hormone levels and allow patients to take lower doses of their usual steroid medications. Participants will receive either atumeln…

This study looks at whether people with inflammatory or autoimmune diseases can safely stop taking steroids (like prednisone) right away instead of slowly reducing the dose over 4 weeks. The goal is to see if stopping quickly leads to more hospital visits or adrenal crises. About…

This study is testing whether the drug ravulizumab can help people with generalized myasthenia gravis (gMG) safely reduce or stop taking oral steroids. About 75 adults who are already on ravulizumab and taking at least 7.5 mg of prednisone daily will follow a gradual steroid-tape…

This early-stage trial is testing a new drug called Lu AG13909 in 42 adults with congenital adrenal hyperplasia (CAH), a rare genetic condition that disrupts hormone production. The study aims to check the drug's safety, how it moves through the body, and its effects on hormone l…

This study tests whether the drug Isturisa can improve blood sugar, cholesterol, blood pressure, weight, and bone strength in people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Ten adults with MACS will take Isturisa for two…

This study tests a low dose of the drug osilodrostat in 15 adults with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. The goal is to see if the drug is safe and can help balance cortisol levels. Participants will take the pill and b…

This study tests whether a once-daily dual-release hydrocortisone pill (Plenadren) works better than standard multiple-dose glucocorticoids for adults with congenital adrenal hyperplasia. The trial will enroll 150 adults and measure changes in cholesterol, blood sugar, weight, bl…

This study aims to find the most accurate cortisol levels to diagnose adrenal insufficiency, a condition where the body doesn't make enough cortisol. Researchers will test 90 healthy volunteers and people already diagnosed with the condition using a new, highly specific cortisol …

This observational study will measure salivary cortisol in 220 healthy adults and people with Cushing's syndrome or adrenal insufficiency. The goal is to establish normal reference ranges and find the best cut-off values for diagnosis. Researchers will compare two lab methods to …

This study looks at whether taking extra hydrocortisone during times of mild to moderate stress (physical or mental) can improve health-related quality of life, especially fatigue, in people with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA) who are on long-term, low…

This study tests whether a low dose of hydrocortisone (a cortisol-like hormone) can reduce symptoms like fatigue and dizziness in people who have recently stopped taking prednisolone for giant cell arteritis or polymyalgia rheumatica. About 100 adults aged 50 and older will recei…

This study at the National Institutes of Health is looking at 1,000 adults with known or suspected hormone gland (endocrine) disorders. The goal is to better understand these conditions and help train doctors. Participants may receive tests, treatments, or surgery as part of thei…

This natural history study aims to gather information from up to 3,000 people with genetic conditions that cause too much androgen (male-like hormones), such as congenital adrenal hyperplasia (CAH) and familial male-limited precocious puberty (FMPP). Participants undergo various …

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study enrolls adults with known or suspected endocrine (hormone gland) disorders, such as diabetes or thyroid disease, to help researchers learn more about these conditions. Participants will undergo medical exams, blood and imaging tests, and possibly genetic testing. The m…

This study looks at how often children with leukemia or lymphoma develop a shortage of natural stress hormones after high-dose steroid treatment. Researchers will test 40 children during and after therapy to see how long the deficiency lasts and who is most at risk. The goal is t…

This study follows 521 patients who had adrenal gland surgery for primary aldosteronism, a condition causing high blood pressure. Researchers want to see how often the remaining adrenal gland fails to produce enough cortisol after surgery, especially in patients who also had extr…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study looks at how women with a severe form of congenital adrenal hyperplasia (classic 21-hydroxylase deficiency) become pregnant and what happens during their pregnancies. Researchers will collect information from medical records and phone interviews with 200 adult women. T…

This study looks at newborns who lose too much salt due to rare hormone problems that can be mistaken for a more common condition called congenital adrenal hyperplasia. Researchers want to find out how often these rare conditions happen and describe their symptoms, genetics, and …

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This study tests a special radioactive tracer called [18F]FNP-59 to see if it can safely and clearly show cholesterol activity in the adrenal gland using PET scans. About 24 people will take part, including healthy volunteers and those with known adrenal problems. The goal is to …

This study is building a large group of 600 adults with various adrenal diseases, like Cushing's syndrome and adrenal tumors. Researchers will track their standard treatments (surgery, radiation, or medication) and outcomes. The goal is to learn more about these conditions, impro…

This study collects medical and genetic information from people with SPLIS, a rare condition caused by a faulty enzyme. Researchers will track survival and when kidney problems start. No treatments are given, but the registry may help future research.