New pill could help kids with rare hormone disorder cut back on steroids

NCT ID NCT07159841

Recruiting now Disease control Sponsor: Crinetics Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a daily oral medication called atumelnant in children aged 1 to 18 with classic congenital adrenal hyperplasia, a genetic condition that disrupts hormone production. The goal is to see if the drug can safely normalize hormone levels and allow patients to lower their daily steroid doses. The trial includes a placebo group and a long-term extension to monitor lasting effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

atumelnant (CRN04894), a daily oral tablet

What this could lead to

If successful, this could offer a new treatment option that helps children with congenital adrenal hyperplasia better control their hormone levels and reduce their dependence on high-dose steroids.

What could go wrong

This is an early-to-mid-stage trial with only 153 participants, so results may not apply to all patients. The drug may cause side effects or fail to show clear benefit over placebo.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

classic congenital adrenal hyperplasia classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency congenital adrenal hyperplasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLASSIC CONGENITAL ADRENAL HYPERPLASIA CONGENITAL ADRENAL HYPERPLASIA

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AOU Federico II
RECRUITING

Naples, Campania, 80131, Italy
APHM -Hopital La Timone Enfants
RECRUITING

Marseille, 13385 Cedex 5, France
Azienda Ospedaliera Universitaria Meyer IRCCS
RECRUITING

Florence, Tuscany, 50139, Italy
Boston's Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
CEDIE "Centro de Investigaciones Endocrinológicas", CONICET-FEI División de Endocrinología, Hosp de Niños Ricardo Gutiérrez
RECRUITING

Buenos Aires, C1425EFD, Argentina
Centre Hospitalier Universitaire (CHU) d'Angers
RECRUITING

Angers, 49100, France
Charité - Universitätsmedizin Berlin Campus Virchow-Klinikum Klinik für pädiatrische Endokrinologie und Diabetologie
RECRUITING

Berlin, 13353, Germany
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, Brussels Capital, 1200, Belgium
Cook Children's Health Care System
RECRUITING

Fort Worth, Texas, 76104, United States
Hopital Jeanne de Flandre - CHU de Lille
RECRUITING

Lille, 59037, France
Hopital Kremlin-Bicétre - APHP Paris Saclay
RECRUITING

Le Kremlin-Bicêtre, 94270, France
Hopital Necker - Enfants Malades
RECRUITING

Paris, 75015, France
Hopital Robert Debre
RECRUITING

Paris, 75019, France
Hospital Italiano de Buenos Aires
RECRUITING

Buenos Aires, C1199ABB, Argentina
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP)
RECRUITING

São Paulo, São Paulo, 05403-000, Brazil
Hospital de Niños de la Santísima Trinidad
RECRUITING

Córdoba, Córdoba Province, X5000, Argentina
IRCCS Istituto Giannina Gaslini
RECRUITING

Genoa, Liguria, 16147, Italy
IRCCS Ospedale San Raffaele
RECRUITING

Milan, Lombardy, 20132, Italy
Institute of Endocrinology of Diabetes, The Children's Hospital at Westmead
NOT_YET_RECRUITING

Westmead, New South Wales, 2145, Australia
Instituto Médico Especializado (IME)
RECRUITING

Buenos Aires, C1405BCH, Argentina
Instituto de Investigaciones Metabólicas
RECRUITING

Buenos Aires, Buenos Aires, C1012AAR, Argentina
Monash Children's Hospital, Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
Perth Children's Hospital
NOT_YET_RECRUITING

Nedlands, Western Australia, 6009, Australia
Queensland Children's Hospital
NOT_YET_RECRUITING

South Brisbane, Queensland, 4101, Australia
Rutgers Robert Wood Johnson Medical School
RECRUITING

New Brunswick, New Jersey, 08901, United States
Sheffield Children's Hospital NHS Trust, Sheffield Children's Hospital, Western Bank
RECRUITING

Sheffield, S10 2TH, United Kingdom
UZ Gent (University Hospital Ghent)
RECRUITING

Ghent, East Flanders, 9000, Belgium
UZ Leuven (Universitair Ziekenhuis Leuven)
RECRUITING

Leuven, Flemish Brabant, 3000, Belgium
UZA (Antwerp University Hospital)
RECRUITING

Edegem, Antwerp, 2650, Belgium
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55454, United States
University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22903, United States
Uniwersytecki Szpital Kliniczny Nr 1 im. Prof. Tadeusza Sokotowskiego PUM w Szczecinie, Centrum Wsparcia Badan Klinicznych Pomorskiego Uniwersytetu Medycznego w Szczecinie
RECRUITING

Szczecin, West Pomeranian Voivodeship, 71-252, Poland
lnstytut Centrum Zdrowia Matki Polki, Klinika Endokrynologii i Chor6b Metabolicznych
RECRUITING

Lodz, Poland, 93-338, Poland