New pill could help kids with rare hormone disorder cut back on steroids

NCT ID NCT07159841

Recruiting now Disease control Sponsor: Crinetics Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 5 times

Summary

This study tests a daily oral medication called atumelnant in children aged 1 to 18 with classic congenital adrenal hyperplasia, a genetic condition that disrupts hormone production. The goal is to see if the drug can safely normalize hormone levels and allow patients to lower their daily steroid doses. The trial includes a placebo group and a long-term extension to monitor lasting effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: atumelnant (CRN04894), a daily oral tablet
What this could lead to: If successful, this could offer a new treatment option that helps children with congenital adrenal hyperplasia better control their hormone levels and reduce their dependence on high-dose steroids.
What could go wrong: This is an early-to-mid-stage trial with only 153 participants, so results may not apply to all patients. The drug may cause side effects or fail to show clear benefit over placebo.

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Conditions

The condition(s) this trial relates to.

classic congenital adrenal hyperplasia classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency congenital adrenal hyperplasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLASSIC CONGENITAL ADRENAL HYPERPLASIA CONGENITAL ADRENAL HYPERPLASIA

Contacts and locations

Locations

AOU Federico II
RECRUITING

Naples, Campania, 80131, Italy
APHM -Hopital La Timone Enfants
RECRUITING

Marseille, 13385 Cedex 5, France
Azienda Ospedaliera Universitaria Meyer IRCCS
RECRUITING

Florence, Tuscany, 50139, Italy
Boston's Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
CEDIE "Centro de Investigaciones Endocrinológicas", CONICET-FEI División de Endocrinología, Hosp de Niños Ricardo Gutiérrez
RECRUITING

Buenos Aires, C1425EFD, Argentina
Centre Hospitalier Universitaire (CHU) d'Angers
RECRUITING

Angers, 49100, France
Charité - Universitätsmedizin Berlin Campus Virchow-Klinikum Klinik für pädiatrische Endokrinologie und Diabetologie
RECRUITING

Berlin, 13353, Germany
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, Brussels Capital, 1200, Belgium
Cook Children's Health Care System
RECRUITING

Fort Worth, Texas, 76104, United States
Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street Hospital
RECRUITING

London, WC1N 3JH, United Kingdom
Hopital Jeanne de Flandre - CHU de Lille
RECRUITING

Lille, 59037, France
Hopital Kremlin-Bicétre - APHP Paris Saclay
RECRUITING

Le Kremlin-Bicêtre, 94270, France
Hopital Necker - Enfants Malades
RECRUITING

Paris, 75015, France
Hopital Robert Debre
RECRUITING

Paris, 75019, France
Hospital Italiano de Buenos Aires
RECRUITING

Buenos Aires, C1199ABB, Argentina
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP)
RECRUITING

São Paulo, São Paulo, 05403-000, Brazil
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
RECRUITING

Ribeirão Preto, São Paulo, 14051-140, Brazil
Hospital de Niños de la Santísima Trinidad
RECRUITING

Córdoba, Córdoba Province, X5000, Argentina
Hospital las Hilgueras de Talcahuano
RECRUITING

Talcahuano, 4270918, Chile
IRCCS Istituto Giannina Gaslini
RECRUITING

Genoa, Liguria, 16147, Italy
IRCCS Ospedale San Raffaele
RECRUITING

Milan, Lombardy, 20132, Italy
Icahn School of Medicine at Mount Sinai-Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Institute of Endocrinology of Diabetes, The Children's Hospital at Westmead
NOT_YET_RECRUITING

Westmead, New South Wales, 2145, Australia
Instituto Médico Especializado (IME)
RECRUITING

Buenos Aires, C1405BCH, Argentina
Instituto de Investigaciones Metabólicas
RECRUITING

Buenos Aires, Buenos Aires, C1012AAR, Argentina
Manchester University NHS Foundation Trust, Royal Manchester Children's Hospital
RECRUITING

Manchester, M13 9WL, United Kingdom
Monash Children's Hospital, Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
Nucleo de Pesquisa Clinica do Rio Grande do Sul
RECRUITING

Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Perth Children's Hospital
NOT_YET_RECRUITING

Nedlands, Western Australia, 6009, Australia
Queensland Children's Hospital
NOT_YET_RECRUITING

South Brisbane, Queensland, 4101, Australia
Radboudumc Amalia Children's Hospital, Department of Pediatrics
RECRUITING

Nijmegen, Gelderland, 6525 GA, Netherlands
Rutgers Robert Wood Johnson Medical School
RECRUITING

New Brunswick, New Jersey, 08901, United States
Sheffield Children's Hospital NHS Trust, Sheffield Children's Hospital, Western Bank
RECRUITING

Sheffield, S10 2TH, United Kingdom
UCSF Ron Conway Gateway Medical Building
RECRUITING

San Francisco, California, 94158, United States
UZ Gent (University Hospital Ghent)
RECRUITING

Ghent, East Flanders, 9000, Belgium
UZ Leuven (Universitair Ziekenhuis Leuven)
RECRUITING

Leuven, Flemish Brabant, 3000, Belgium
UZA (Antwerp University Hospital)
RECRUITING

Edegem, Antwerp, 2650, Belgium
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55454, United States
University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22903, United States
Universitätsklinikum Tübingen Klinik fur Kinder und Jugendmedizin
RECRUITING

Tübingen, Baden, 72076, Germany
Uniwersytecki Szpital Kliniczny Nr 1 im. Prof. Tadeusza Sokotowskiego PUM w Szczecinie, Centrum Wsparcia Badan Klinicznych Pomorskiego Uniwersytetu Medycznego w Szczecinie
RECRUITING

Szczecin, West Pomeranian Voivodeship, 71-252, Poland
lnstytut Centrum Zdrowia Matki Polki, Klinika Endokrynologii i Chor6b Metabolicznych
RECRUITING

Lodz, Poland, 93-338, Poland

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