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Could a simple saliva test replace blood draws for hormone monitoring?

NCT ID NCT07718230

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study explores whether at-home saliva samples can reliably measure key steroid hormones in people with congenital adrenal hyperplasia (CAH), a condition requiring lifelong hormone therapy. Currently, monitoring involves morning blood tests that miss daily hormone fluctuations. Researchers will compare steroid levels from multiple saliva samples collected throughout the day with standard blood tests to see if saliva offers a practical, less invasive alternative.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simpler, less invasive way to monitor hormone levels in people with congenital adrenal hyperplasia, replacing some blood tests.
What could go wrong
This is a small, early-stage observational study. Saliva measurements may not match blood levels closely enough to be clinically useful, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pediatric patients with congenital adrenal hyperplasia followed in the pediatric endocrinology departments of Hôpital Armand Trousseau (Centre de Référence Maladies Endocriniennes Rares de la Croissance) and Hôpital Bicêtre (Service d'Endocrinologie et diabète de l'Enfant, Centre de Référence DevGen), seen during their routine follow-up visits.

Ages

6 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 6 years or older * Confirmed diagnosis of congenital adrenal hyperplasia treated with glucocorticoids * Signed informed consent provided by legal guardians * Affiliation to a national health insurance system Exclusion Criteria: * Patients younger than 6 years of age * Lesions of the oral mucosa that could interfere with saliva sampling * Inability to provide the patient or legal representatives with appropriate study information (e.g., poor understanding of French) * Underage parents * Lack of affiliation with a social security/health insurance system

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Conditions

The condition(s) this trial relates to.

adrenocortical insufficiency classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency congenital adrenal hyperplasia Hyperandrogenism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adrenal insufficiency Congenital adrenal hyperplasia Hyperandrogenism; 21-hydroxylase deficiency

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Service des Explorations Fonctionnelles Endocriniennes, Hôpital Armand Trousseau

    Paris, 75012, France

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