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Could a simple saliva test replace blood draws for hormone monitoring?

NCT ID NCT07718230

Not yet recruiting Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study explores whether at-home saliva samples can reliably measure key steroid hormones in people with congenital adrenal hyperplasia (CAH), a condition requiring lifelong hormone therapy. Currently, monitoring involves morning blood tests that miss daily hormone fluctuations. Researchers will compare steroid levels from multiple saliva samples collected throughout the day with standard blood tests to see if saliva offers a practical, less invasive alternative.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simpler, less invasive way to monitor hormone levels in people with congenital adrenal hyperplasia, replacing some blood tests.
What could go wrong
This is a small, early-stage observational study. Saliva measurements may not match blood levels closely enough to be clinically useful, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adrenocortical insufficiency classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency congenital adrenal hyperplasia Hyperandrogenism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADRENAL INSUFFICIENCY CONGENITAL ADRENAL HYPERPLASIA HYPERANDROGENISM; 21-HYDROXYLASE DEFICIENCY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Service des Explorations Fonctionnelles Endocriniennes, Hôpital Armand Trousseau

    Paris, 75012, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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