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Could a Once-Daily pill replace Twice-Daily dosing for adrenal gland recovery?

NCT ID NCT07703098

Not yet recruiting Disease control Sponsor: University Medical Centre Ljubljana Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study compares two steroid replacement therapies—methylprednisolone and hydrocortisone—in people whose adrenal glands have stopped working properly due to long-term use of high-dose steroids. The goal is to see whether a single morning dose of methylprednisolone is as good as or better than the standard twice-daily hydrocortisone at helping the adrenal glands recover. Participants take one of the two medications for 12 months, and their adrenal function is tested with a short ACTH stimulation test.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
methylprednisolone and hydrocortisone
What this could lead to
If methylprednisolone works as well or better than hydrocortisone, it could offer a simpler, once-daily treatment option for people with adrenal insufficiency caused by steroid use.
What could go wrong
This is a small, early-phase trial with only 66 participants, so results may not apply to everyone. The study compares two existing drugs, so no breakthrough is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adrenocortical insufficiency secondary adrenal insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADRENAL INSUFFICIENCY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UMC Ljubljana

    Ljubljana, 1000, Slovenia

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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