ADRENAL INSUFFICIENCY

This study aims to find the most accurate cortisol levels to diagnose adrenal insufficiency, a condition where the body doesn't make enough cortisol. Researchers will test 90 healthy volunteers and people already diagnosed with the condition using a new, highly specific cortisol …

This observational study will measure cortisol in saliva from 220 healthy adults to establish normal reference ranges. Researchers will also determine the best cut-off values to diagnose Cushing's syndrome (too much cortisol) and adrenal insufficiency (too little cortisol). The g…

This study looks at whether taking extra hydrocortisone during times of stress (like illness or emotional strain) can improve fatigue and daily well-being in people whose adrenal glands are underactive due to long-term prednisolone treatment for polymyalgia rheumatica or giant ce…

This study tests whether a low dose of hydrocortisone can relieve symptoms like fatigue and feeling unwell in people who have stopped taking prednisolone for giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). About 100 adults aged 50 and older who have been off steroids …

This study aims to learn more about endocrine and metabolic disorders in children by examining their genes. Researchers will evaluate up to 15,000 children aged 3 months to 18 years with known or suspected conditions, along with their family members. The goal is to identify genet…

This study follows 521 patients who had adrenal gland surgery for primary aldosteronism, some of whom also have extra cortisol production. Researchers want to see how often the remaining adrenal gland fails to make enough cortisol after surgery, how long it takes to recover, and …

This study looks at how often children treated for leukemia or lymphoma develop a shortage of natural stress hormones (cortisol) after receiving high-dose steroids. Researchers will test 40 children at two Swiss hospitals to see how long the shortage lasts and which kids are most…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already taking these drugs as part of their regular care, or have had a recent CO…