Stress relief: could a simple hormone boost ease fatigue in PMR/GCA patients?

NCT ID NCT05435781

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether taking extra hydrocortisone during times of mild to moderate stress (physical or mental) can improve health-related quality of life, especially fatigue, in people with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA) who are on long-term, low-dose prednisolone. Participants will be randomly assigned to receive either hydrocortisone or a placebo during stressful periods and will report their symptoms via a smartphone app. The goal is to see if this approach helps manage fatigue and other stress-related symptoms.

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Conditions

The condition(s) this trial relates to.

adrenocortical insufficiency Giant Cell Arteritis polymyalgia rheumatica secondary adrenal insufficiency temporal arteritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Department of Endocrinology, Aarhus University Hospital

    RECRUITING

    Aarhus, Denmark

    Contact

  • Department of Endocrinology, Odense University Hospital

    RECRUITING

    Odense, Denmark

    Contact

  • Department of Medical Endocrinology, Copenhagen University Hospital, Rigshospitalet

    RECRUITING

    Copenhagen, 2100, Denmark

    Contact

    Contact Email: •••••@•••••

    Contact