New tool could predict who will suffer from steroid side effects

NCT ID NCT04664465

Ongoing Knowledge-focused Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such as blood tests, bone density scans, and patient history—from 300 people starting high-dose steroids. The goal is to build a simple score that helps doctors personalize treatment and reduce harm.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: glucocorticoid therapy (prednisone or equivalent)
What this could lead to: If successful, doctors could use a simple score to predict steroid side effects and tailor treatment plans for each patient.
What could go wrong: This is an observational study, not a treatment trial. The predictive score may not be accurate enough for routine use and needs further validation.

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Conditions

The condition(s) this trial relates to.

acquired idiopathic inflammatory myopathy anti-neutrophil cytoplasmic antibody-associated vasculitis autoimmune disease Giant Cell Arteritis granulomatosis with polyangiitis myositis disease polymyalgia rheumatica rheumatic disorder rheumatic fever temporal arteritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANCA-ASSOCIATED VASCULITIS GIANT CELL ARTERITIS IDIOPATHIC INFLAMMATORY MYOPATHIES INFLAMMATORY RHEUMATISM POLYMYALGIA RHEUMATICA SYSTEMIC AUTOIMMUNE DISEASE

Contacts and locations

Locations

<CHU de Poitiers

Poitiers, France
CH Le Mans

Le Mans, 72000, France
CH des Pays de Morlaix

Morlaix, 29672, France
CHD Vendée

La Roche-sur-Yon, 85925, France
CHIC Quimper

Quimper, 29000, France
CHR d'Orléans

Orléans, 45067, France
CHRU de Brest

Brest, 29609, France
CHU d'Angers

Angers, 49933, France
CHU de Nantes - Service de Médecine interne

Nantes, 44093, France
CHU de Nantes - Service de Rhumatologie

Nantes, 44093, France
CHU de Tours

Tours, 37044, France
Clinique St Exupéry

Toulouse, France

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