New pill may help adults with rare adrenal disorder cut back on steroids

NCT ID NCT07144163

Recruiting now Disease control Sponsor: Crinetics Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 3 times

Summary

This study tests a new drug, atumelnant, in 150 adults with classic congenital adrenal hyperplasia (CAH). The goal is to see if it can safely control hormone levels and allow patients to take lower doses of their usual steroid medications. Participants will receive either atumelnant or a placebo, and researchers will monitor hormone levels and side effects over time.

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Conditions

The condition(s) this trial relates to.

classic congenital adrenal hyperplasia classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency congenital adrenal hyperplasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLASSIC CONGENITAL ADRENAL HYPERPLASIA CONGENITAL ADRENAL HYPERPLASIA

Contacts and locations

Locations

Crinetics Study Site
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Los Angeles, California, 90027, United States
Crinetics Study Site
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Aurora, Colorado, 80045, United States
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Atlanta, Georgia, 30322, United States
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Chicago, Illinois, 60611, United States
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Baltimore, Maryland, 21287, United States
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Ann Arbor, Michigan, 48109, United States
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Minneapolis, Minnesota, 55417, United States
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Rochester, Minnesota, 55905, United States
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Philadelphia, Pennsylvania, 19104, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Dallas, Texas, 75390, United States
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Milwaukee, Wisconsin, 53226, United States
Crinetics Study Site
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Buenos Aires, Buenos Aires F.D., 1405, Argentina
Crinetics Study Site
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Buenos Aires, Buenos Aires F.D., C1012AAR, Argentina
Crinetics Study Site
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CABA, Buenos Aires F.D., 1119, Argentina
Crinetics Study Site
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CABA, Buenos Aires F.D., C1199ABB, Argentina
Crinetics Study Site
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Córdoba, Córdoba Province, X5000JRD, Argentina
Crinetics Study Site
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Herston, Queensland, 4029, Australia
Crinetics Study Site
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Woolloongabba, Queensland, 4102, Australia
Crinetics Study Site
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Adelaide, South Australia, 5000, Australia
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Parkville, Victoria, 3050, Australia
Crinetics Study Site
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Nedlands, Western Australia, 6009, Australia
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Vienna, 1090, Austria
Crinetics Study Site
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Fortaleza, Ceará, 60430-275, Brazil
Crinetics Study Site
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Curitiba, Paraná, 80030-110, Brazil
Crinetics Study Site
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Rio de Janeiro, Rio de Janeiro, 20231-092, Brazil
Crinetics Study Site
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Rio de Janeiro, Rio de Janeiro, 20551-030, Brazil
Crinetics Study Site
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Porto Alegre, Rio Grande do Sul, 90410-000, Brazil
Crinetics Study Site
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Botucatu, São Paulo, 18618-686, Brazil
Crinetics Study Site
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Ribeirão Preto, São Paulo, 14051-140, Brazil
Crinetics Study Site
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São Paulo, São Paulo, 04024-002, Brazil
Crinetics Study Site
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São Paulo, São Paulo, 05403-000, Brazil
Crinetics Study Site
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Angers, 49933, France
Crinetics Study Site
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Bron, 69500, France
Crinetics Study Site
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Nantes, 44093 Cedex 1, France
Crinetics Study Site
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Paris, 75013, France
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Pessac, 33604, France
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Vandœuvre-lès-Nancy, 54500, France
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Munich, Bavaria, 80336, Germany
Crinetics Study Site
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Würzburg, 97080, Germany
Crinetics Study Site
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Genova, Genova, 16132, Italy
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Milan, Milano, 20132, Italy
Crinetics Study Site
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Milan, Milano, 20149, Italy
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Rozzano, Milano, 20089, Italy
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Modena, Modena, 41126, Italy
Crinetics Study Site
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Padova, Padova, 35128, Italy
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Palermo, Palermo, 90127, Italy
Crinetics Study Site
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Naples, 80131, Italy
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Roma, 00161, Italy
Crinetics Study Site
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Bunkyo-ku, Tokyo, 113-8519, Japan
Crinetics Study Site
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Fuchu-shi, Tokyo, 183-8561, Japan
Crinetics Study Site
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Shinjuku-ku, Tokyo, 162-8655, Japan
Crinetics Study Site
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Shinjuku-ku, Tokyo, 162-8666, Japan
Crinetics Study Site
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Leiden, South Holland, 2333 ZA, Netherlands
Crinetics Study Site
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Poznan, Greater Poland Voivodeship, 60-354, Poland
Crinetics Study Site
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Warsaw, Masovian Voivodeship, 00-189, Poland
Crinetics Study Site
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Lodz, Łódź Voivodeship, 93-338, Poland
Crinetics Study Site
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Riyadh, Riyadh Region, 11211, Saudi Arabia
Crinetics Study Site
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Gothenburg, 413 46, Sweden
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Stockholm, 171 76, Sweden
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Cardiff, Wales, CF14 4xW, United Kingdom
Crinetics Study Site
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London, NW1 2PG, United Kingdom
Crinetics Study Site
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Manchester, M20 4BX, United Kingdom

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