New pill aims to tame hidden cortisol problem

NCT ID NCT07104812

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a low dose of the drug osilodrostat in 15 adults with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. The goal is to see if the drug is safe and can help balance cortisol levels. Participants will take the pill and be monitored for side effects and hormone changes.

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Conditions

The condition(s) this trial relates to.

ACTH-independent Cushing syndrome congenital adrenal hyperplasia Cushing syndrome ectopic ACTH secretion syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTONOMOUS CORTISOL SECRETION (ACS) MILD AUTONOMOUS CORTISOL SECRETION

Contacts and locations

Locations

Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States

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